一名感染人冠状病毒HCoV-229E的婴儿发生急性危及生命事件（ALTE）。
Acute life threatening event (ALTE) in an infant with human coronavirus HCoV-229E infection.
作者信息
Simon Arne, Völz Sebastian, Höfling Katja, Kehl Alexandra, Tillman Ramona, Müller Andreas, Kupfer Bernd, Eis-Hübinger Anna-Maria, Lentze Michael J, Bode Udo, Schildgen Oliver
机构信息
Children's Hospital Medical Centre, University of Bonn, Bonn, Germany.
出版信息
Pediatr Pulmonol. 2007 Apr;42(4):393-6. doi: 10.1002/ppul.20595.
Abstract
In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT-PCR confirmed coronavirus HCoV-229E infection in a 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs of a respiratory tract infection may help to clarify the etiology in some patients and extend our understanding of the pathogenesis. PCR-based techniques should be utilized to increase the sensitivity of detection for old and new respiratory viral pathogens in comparable cases.
摘要
在本简短报告中，我们讨论了一名4个月大、其他方面健康的婴儿发生的急性危及生命事件（ALTE）与逆转录聚合酶链反应（RT-PCR）确诊的冠状病毒HCoV-229E感染之间的时间关联。对受影响儿童进行更详细的微生物学调查，即使没有明显的呼吸道感染迹象，也可能有助于阐明某些患者的病因，并扩展我们对发病机制的理解。在类似病例中，应采用基于PCR的技术来提高对新旧呼吸道病毒病原体的检测灵敏度。
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