海马体神经发生对工作记忆的矛盾影响。
Paradoxical influence of hippocampal neurogenesis on working memory.
作者信息
Saxe Michael D, Malleret Gaël, Vronskaya Svetlana, Mendez Indira, Garcia A Denise, Sofroniew Michael V, Kandel Eric R, Hen René
机构信息
Center for Neurobiology and Behavior and Howard Hughes Medical Institute, Columbia University, 722 West 168th Street, New York, NY 10032, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4642-6. doi: 10.1073/pnas.0611718104. Epub 2007 Mar 5.
Abstract
To explore the function of adult hippocampal neurogenesis, we ablated cell proliferation by using two independent and complementary methods: (i) a focal hippocampal irradiation and (ii) an inducible and reversible genetic elimination of neural progenitor cells. Previous studies using these methods found a weakening of contextual fear conditioning but no change in spatial reference memory, suggesting a supportive role for neurogenesis in some, but not all, hippocampal-dependent memory tasks. In the present study, we examined hippocampal-dependent and -independent working memory using different radial maze tasks. Surprisingly, ablating neurogenesis caused an improvement of hippocampal-dependent working memory when repetitive information was presented in a single day. These findings suggest that adult-born cells in the dentate gyrus have different, and in some cases, opposite roles in distinct types of memory.
摘要
为了探究成年海马体神经发生的功能，我们使用了两种独立且互补的方法来消除细胞增殖：（i）海马体局部照射和（ii）神经祖细胞的诱导性和可逆性基因消除。此前使用这些方法的研究发现情境恐惧条件反射减弱，但空间参考记忆没有变化，这表明神经发生在某些但并非所有海马体依赖性记忆任务中起支持作用。在本研究中，我们使用不同的放射状迷宫任务来检测海马体依赖性和非依赖性工作记忆。令人惊讶的是，当在一天内呈现重复信息时，消除神经发生会导致海马体依赖性工作记忆得到改善。这些发现表明，齿状回中成年新生细胞在不同类型的记忆中具有不同的，在某些情况下甚至相反的作用。
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本文引用的文献
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Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus.海马神经发生的消融会损害齿状回中的情境恐惧条件反射和突触可塑性。
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Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment.环境富集的行为效应并不需要海马体神经发生。
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