Josyula Arun B, McClellen Hannah, Hysong Tracy A, Kurzius-Spencer Margaret, Poplin Gerald S, Stürup Stefan, Burgess Jefferey L
Environmental and Occupational Health, Mel and Enid Zuckerman College of Public Health, University ofArizona, Tucson, AZ 85719, USA.
J Health Popul Nutr. 2006 Sep;24(3):298-304.
The study was conducted to measure the effectiveness of providing bottled water in reducing arsenic exposure. Urine, tap-water and toenail samples were collected from non-smoking adults residing in Ajo (n=40) and Tucson (n=33), Arizona, USA. The Ajo subjects were provided bottled water for 12 months prior to re-sampling. The mean total arsenic (microg/L) in tap-water was 20.3+/-3.7 in Ajo and 4.0+/-2.3 in Tucson. Baseline urinary total inorganic arsenic (microg/L) was significantly higher among the Ajo subjects (n=40, 29.1+/-20.4) than among the Tucson subjects (n=32, 11.0+/-12.0, p<0.001), as was creatinine-adjusted urinary total inorganic arsenic (microg/g) (35.5+/-25.2 vs 13.2+/-9.3, p<0.001). Baseline concentrations of arsenic (microg/g) in toenails were also higher among the Ajo subjects (0.51+/-0.72) than among the Tucson subjects (0.17+/-0.21) (p<0.001). After the intervention, the mean urinary total inorganic arsenic in Ajo (n=36) dropped by 21%, from 29.4+/-21.1 to 23.2+/-23.2 (p=0.026). The creatinine-adjusted urinary total inorganic arsenic and toenail arsenic levels did not differ significantly with the intervention. Provision of arsenic-free bottled water resulted in a modest reduction in urinary total inorganic arsenic.
本研究旨在衡量提供瓶装水在降低砷暴露方面的有效性。从居住在美国亚利桑那州阿霍（n = 40）和图森（n = 33）的不吸烟成年人中收集尿液、自来水和脚趾甲样本。在重新采样前，为阿霍的受试者提供了12个月的瓶装水。阿霍自来水中总砷的平均含量（微克/升）为20.3±3.7，图森为4.0±2.3。阿霍受试者（n = 40，29.1±20.4）的基线尿总无机砷含量（微克/升）显著高于图森受试者（n = 32，11.0±12.0，p<0.001），肌酐校正后的尿总无机砷含量（微克/克）也是如此（35.5±25.2对13.2±9.3，p<0.001）。阿霍受试者脚趾甲中砷的基线浓度（微克/克）（0.51±0.72）也高于图森受试者（0.17±0.21）（p<0.001）。干预后，阿霍（n = 36）的尿总无机砷平均含量下降了21%，从29.4±21.1降至23.2±23.2（p = 0.026）。肌酐校正后的尿总无机砷和脚趾甲砷水平在干预后无显著差异。提供无砷瓶装水使尿总无机砷略有降低。
