Chen Xi-Kuan, Wen Shi Wu, Fleming Nathalie, Yang Qiuying, Walker Mark C
OMNI Research Group, Department of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
Hum Reprod. 2007 Jun;22(6):1730-5. doi: 10.1093/humrep/dem043. Epub 2007 Mar 19.
Teenage pregnancy may be associated with some forms of congenital anomalies. The objective of this study was to identify the types of congenital anomalies associated with teenage pregnancy.
We carried out a retrospective cohort study of 5 542 861 nulliparous pregnant women younger than 35 years of age with a live singleton birth between 1995 and 2000 in the USA.
Compared with adult pregnancy (20-34 years old), and after adjustment for confounding variables, teenage pregnancy (13-19 years old) was associated with increased risk of central nervous system anomalies [odds ratio (OR) 1.08; 95% confidence interval (CI): 1.01, 1.16], gastrointestinal anomalies (OR: 1.39; 95% CI: 1.31, 1.49) and musculoskeletal/integumental anomalies (OR: 1.06; 95% CI: 1.03, 1.10). The teenage pregnancy associated increase in risk for central nervous system anomalies was mainly attributable to anomalies other than anencephalus, spina bifida/meningocele and hydrocephalus and microcephalus; for gastrointestinal anomalies the risk was mainly attributable to omphalocele/gastroschisis; and for musculoskeletal/integumental anomalies the risk was mainly attributable to cleft lip/palate and polydactyly/syndactyly/adactyly. No increased risk was found for circulatory/respiratory anomalies, urogenital anomalies, or Down's syndrome.
Teenage pregnancy increases the risks of congenital anomalies in central nervous, gastrointestinal and musculoskeletal/integumental systems.
青少年怀孕可能与某些先天性异常形式相关。本研究的目的是确定与青少年怀孕相关的先天性异常类型。
我们对1995年至2000年在美国的5542861名年龄小于35岁、单胎活产的未生育孕妇进行了一项回顾性队列研究。
与成年妊娠（20 - 34岁）相比，在对混杂变量进行调整后，青少年妊娠（13 - 19岁）与中枢神经系统异常风险增加相关[比值比（OR）1.08；95%置信区间（CI）：1.01，1.16]、胃肠道异常（OR：1.39；95%CI：1.31，1.49）以及肌肉骨骼/皮肤异常（OR：1.06；95%CI：1.03，1.10）。青少年妊娠相关的中枢神经系统异常风险增加主要归因于无脑儿、脊柱裂/脊膜膨出、脑积水和小头畸形以外的异常；胃肠道异常风险主要归因于脐膨出/腹裂；肌肉骨骼/皮肤异常风险主要归因于唇腭裂和多指/并指/无指畸形。未发现循环/呼吸系统异常、泌尿生殖系统异常或唐氏综合征的风险增加。
青少年怀孕会增加中枢神经系统、胃肠道以及肌肉骨骼/皮肤系统先天性异常的风险。
