茴芹（Pimpinella anisum）水悬浮液可保护大鼠免受化学诱导的胃溃疡。
Aqueous suspension of anise "Pimpinella anisum" protects rats against chemically induced gastric ulcers.
作者信息
Al Mofleh Ibrahim A, Alhaider Abdulqader A, Mossa Jaber S, Al-Soohaibani Mohammed O, Rafatullah Syed
机构信息
Department of Medicine, College of Medicine, King Saud University, PO Box 2925 (59), Riyadh 11461, Saudi Arabia.
出版信息
World J Gastroenterol. 2007 Feb 21;13(7):1112-8. doi: 10.3748/wjg.v13.i7.1112.
AIM
To substantiate the claims of Unani and Arabian traditional medicine practitioners on the gastroprotective potential effect of a popular spice anise, "Pimpinella anisum L." on experimentally-induced gastric ulceration and secretion in rats.
METHODS
Acute gastric ulceration in rats was produced by various noxious chemicals including 80% ethanol, 0.2 mol/L NaOH, 25% NaCl and indomethacin. Anti-secretory studies were undertaken using pylorus-ligated Shay rat technique. Levels of gastric non-protein sulfhydryls (NP-SH) and wall mucus were estimated and gastric tissue was also examined histologically. Anise aqueous suspension was used in two doses (250 and 500 mg/kg body weight) in all experiments.
RESULTS
Anise significantly inhibited gastric mucosal damage induced by necrotizing agents and indomethacin. The anti-ulcer effect was further confirmed histologically. In pylorus-ligated Shay rats, anise suspension significantly reduced the basal gastric acid secretion, acidity and completely inhibited the rumenal ulceration. On the other hand, the suspension significantly replenished ethanol-induced depleted levels of gastric mucosal NP-SH and gastric wall mucus concentration.
CONCLUSION
Anise aqueous suspension possesses significant cytoprotective and anti-ulcer activities against experimentally-induced gastric lesions. The anti-ulcer effect of anise is possibly prostaglandin-mediated and/or through its anti-secretory and antioxidative properties.
目的
证实尤那尼医学和阿拉伯传统医学从业者关于一种常见香料茴芹（“Pimpinella anisum L.”）对实验性诱导的大鼠胃溃疡和分泌具有胃保护潜在作用的说法。
方法
通过多种有害化学物质诱导大鼠急性胃溃疡，这些化学物质包括80%乙醇、0.2 mol/L氢氧化钠、25%氯化钠和吲哚美辛。采用幽门结扎的 Shay 大鼠技术进行抗分泌研究。测定胃非蛋白巯基（NP-SH）水平和胃壁黏液水平，并对胃组织进行组织学检查。在所有实验中，使用两种剂量（250和500 mg/kg体重）的茴芹水悬浮液。
结果
茴芹显著抑制坏死剂和吲哚美辛诱导的胃黏膜损伤。组织学进一步证实了其抗溃疡作用。在幽门结扎的 Shay 大鼠中，茴芹悬浮液显著降低基础胃酸分泌、酸度，并完全抑制瘤胃溃疡。另一方面，该悬浮液显著补充了乙醇诱导的胃黏膜NP-SH水平降低和胃壁黏液浓度。
结论
茴芹水悬浮液对实验性诱导的胃损伤具有显著的细胞保护和抗溃疡活性。茴芹的抗溃疡作用可能是由前列腺素介导的和/或通过其抗分泌和抗氧化特性实现的。
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