Desenne J J, Acquatella G, Stern R, Muller A, Sánchez M, Somoza R
Lymphoma Clinic, University Hospital of Caracas, Universidad Central de Venezuela.
Cancer. 1992 Mar 1;69(5):1248-53. doi: 10.1002/cncr.2820690529.
Twenty-five patients with Hodgkin's disease and high eosinophil counts were observed for an average of 90 months. Fluctuations in the levels of eosinophils were important in the course of observation. No relation with stages, histologic type, or evolution was noticed. Steroid-containing regimens and severe premortem conditions seemed to lower the counts. Relapse-free survival was shorter in our 25 patients than in a control group of 50 patients with Hodgkin's disease and no eosinophilia who had approximately the same stage, histologic type, and treatment of disease. However, the overall survival was somewhat better for the eosinophilic patients with stages IIIB and IV (0.1 greater than P greater than 0.05).
对25例霍奇金病且嗜酸性粒细胞计数较高的患者进行了平均90个月的观察。在观察过程中，嗜酸性粒细胞水平的波动很重要。未发现与分期、组织学类型或病情进展有关。含类固醇的治疗方案和临终前的严重状况似乎会降低计数。我们的25例患者的无复发生存期比50例处于大致相同分期、组织学类型且接受相同疾病治疗的无嗜酸性粒细胞增多的霍奇金病对照组患者要短。然而，III B期和IV期嗜酸性粒细胞增多患者的总生存率略高（0.1＞P＞0.05）。
