Yoshihara Toru, Shimada Kenichiroh, Momoi Yasuyuki, Konno Katsuhiko, Iwasaki Toshiroh
Kao Corporation, Tokyo, Japan.
J Vet Med Sci. 2007 Mar;69(3):289-92. doi: 10.1292/jvms.69.289.
Human skin barrier function is evaluated by measuring transepidermal water loss (TEWL). However, this conventional method has not been applied to assess canine skin barrier function because the equipment is not suitable for dogs due to the effects of air turbulence resulting from movement of the subject and vapor from the subject's hair coat. The TEWL analyzer CC-01 was developed as a closed-chamber method device; this means that instead of using the open-chamber method, it has a ventilated chamber that uses dry air. TEWL values measured by CC-01 show less variability than those measured by the conventional method. An ambient temperature of 20-26 degrees C is optimal for measurement with the CC-01, and humidity affects the length of measurement but not the values. The CC-01 may be more reliable for measurement of TEWL than the conventional methods and may give new insights in the evaluation of skin barrier function in dogs.
人类皮肤屏障功能通过测量经表皮水分流失（TEWL）来评估。然而，这种传统方法尚未应用于评估犬类皮肤屏障功能，因为该设备由于受测试对象移动产生的空气湍流以及测试对象毛发上的水汽影响，并不适合犬类。TEWL分析仪CC - 01是作为一种密闭腔室法设备开发的；这意味着它不是使用开放腔室法，而是有一个使用干燥空气的通风腔室。用CC - 01测量的TEWL值比用传统方法测量的更稳定。20 - 26摄氏度的环境温度最适合用CC - 01进行测量，湿度会影响测量时间长度，但不影响测量值。与传统方法相比，CC - 01在测量TEWL方面可能更可靠，并且可能为犬类皮肤屏障功能的评估提供新的见解。
