Haba Yasuhiro, Kojima Chie, Harada Atsushi, Ura Tomoaki, Horinaka Hiromichi, Kono Kenji
Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8531, Japan.
Langmuir. 2007 May 8;23(10):5243-6. doi: 10.1021/la0700826. Epub 2007 Apr 10.
Loading of HAuCl4 in poly(amido amine) G4 dendrimers having poly(ethylene glycol) (PEG) grafts at all chain ends and subsequent reduction with NaBH4 yielded PEG-modified dendrimers encapsulating gold nanoparticles (Au NPs) of ca. 2 nm diameter. The Au NPs held in the dendrimers were stable in aqueous solutions and dissolved readily, even after freeze-drying. Despite their small particle size, the heat-generating ability of Au NPs held in the dendrimer was comparable to that of widely used Au NPs with ca. 11 nm diameter under visible light irradiation. The observed excellent colloidal stability, high heat-generating ability and their biocompatible surface confirm that the PEG-modified dendrimers encapsulating Au NPs are a promising tool for photothermal therapy and imaging.
在所有链端均带有聚乙二醇（PEG）接枝的聚（酰胺胺）G4树枝状大分子中负载HAuCl4，随后用NaBH4还原，得到了包封直径约为2 nm金纳米颗粒（Au NPs）的PEG修饰树枝状大分子。包封在树枝状大分子中的Au NPs在水溶液中稳定，即使经过冷冻干燥也能轻易溶解。尽管其粒径较小，但在可见光照射下，包封在树枝状大分子中的Au NPs产生热量的能力与广泛使用的直径约为11 nm的Au NPs相当。所观察到的优异胶体稳定性、高发热能力及其生物相容性表面证实，包封Au NPs的PEG修饰树枝状大分子是用于光热治疗和成像的有前途的工具。
