Naylor J M
Can Vet J. 1987 Apr;28(4):168-73.
A prospective study of the severity of dehydration and acidosis was carried out in 42 calves under 35 days of age presented for treatment of neonatal diarrhea. Clinically the mean level of dehydration was 8 to 10%. The plasma volume was 65% of that in the hydrated calf but the calves only gained 6.5% in weight during therapy.Calves under eight days of age often had a lactic acidosis. Blood pH was 7.118+/-0.026 (mean +/- 1 standard error), bicarbonate concentration 18.8+/-1.3 mmol/L, base deficit 11.4+/-1.7 mmol/L and lactate of 3.6+/- 0.06 mmol/L. Calves over eight days usually had a nonlactic acidosis. Blood pH was 7.042+/-0.021, bicarbonate 10.8+/-1.0 mmol/L, base deficit 19.5+/-1.2 mmol/L and lactate 1.2+/-0.3 mmol/L. These values were all significantly different from those in younger calves.Over all calves there was a poor correlation between the severity of acidosis and dehydration(r=0.05). The severity of lactic acidosis was related to the severity of dehydration. Mean bicarbonate requirements to correct acidosis were calculated to be 200 mmol(17 g of sodium bicarbonate)and 450 mmol(37 g of sodium bicarbonate)in calves under and over eight days of age respectively. Both groups of calves required a mean volume of 4L of fluid to correct dehydration.
对42头35日龄以下因新生儿腹泻前来治疗的犊牛进行了脱水和酸中毒严重程度的前瞻性研究。临床上，脱水的平均水平为8%至10%。血浆量为水合犊牛的65%，但犊牛在治疗期间体重仅增加了6.5%。8日龄以下的犊牛常出现乳酸酸中毒。血液pH值为7.118±0.026（平均值±1个标准误），碳酸氢盐浓度为18.8±1.3 mmol/L，碱缺失为11.4±1.7 mmol/L，乳酸为3.6±0.06 mmol/L。8日龄以上的犊牛通常出现非乳酸酸中毒。血液pH值为7.042±0.021，碳酸氢盐为10.8±1.0 mmol/L，碱缺失为19.5±1.2 mmol/L，乳酸为1.2±0.3 mmol/L。这些值与较年幼犊牛的值均有显著差异。在所有犊牛中，酸中毒严重程度与脱水之间的相关性较差（r=0.05）。乳酸酸中毒的严重程度与脱水的严重程度相关。计算得出，8日龄以下和8日龄以上的犊牛纠正酸中毒所需的平均碳酸氢盐量分别为200 mmol（17 g碳酸氢钠）和450 mmol（37 g碳酸氢钠）。两组犊牛纠正脱水平均都需要4L液体量。
