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成功治疗一名伴有大面积三度烧伤患者的面部深度烧伤:纳米晶银敷料在促进创面愈合中的作用

Successful management of deep facial burns in a patient with extensive third-degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing.

作者信息

Marazzi Mario, De Angelis Armando, Ravizza Adriano, Ordanini Marco N, Falcone Leonarda, Chiaratti Anna, Crovato Francesca, Calò Donata, Veronese Silvio, Rapisarda Vincenzo

机构信息

Department of Tissue Therapy, Niguarda Ca' Granda Hospital, Milan, Italy.

出版信息

Int Wound J. 2007 Mar;4(1):8-14. doi: 10.1111/j.1742-481X.2006.00263.x.

DOI:10.1111/j.1742-481X.2006.00263.x
PMID:17425544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7951304/
Abstract

Full-thickness burns of the face are notoriously difficult to repair and their management poses a series of problems to the surgeon. We present the case of a 49-year-old man (only survivor of a catastrophic airport accident) with third-degree flame burns to >80% of total body surface area and extensive face damage who achieved a fully satisfactory outcome after a treatment plan based on gradual escharectomy followed by application of artificial dermis and, later, grafting with sheets of cultured keratinocytes. Re-epithelialisation was already visible at day 16 after admission and all facial wounds were closed by day 56, the treatment continuing on the scalp. Within 6 months of the accident, the patient had recovered functional and cosmetic features (including re-growth of skin appendages) that were beyond expectations. The use of nanocrystalline silver-coated dressings during the escharectomy and resurfacing phases was important, as part of a multifaceted strategy, in ensuring excellent antimicrobial control, thus avoiding the need for autologous grafting and contributing to a rapid healing and complete restoration of the face and head skin.

摘要

面部全层烧伤 notoriously 难以修复,其治疗给外科医生带来一系列问题。我们报告一例49岁男性(一场灾难性机场事故的唯一幸存者),其全身表面积超过80%遭受三度火焰烧伤且面部广泛受损,在基于逐步切除焦痂、随后应用人工真皮、并在之后用培养的角质形成细胞片进行移植的治疗方案后,取得了完全令人满意的结果。入院后第16天即可见重新上皮化,到第56天所有面部伤口均已闭合,治疗继续在头皮上进行。事故发生后6个月内,患者恢复了超出预期的功能和外观特征(包括皮肤附属器再生)。在切除焦痂和创面修复阶段使用纳米晶银涂层敷料作为多方面策略的一部分,对于确保出色的抗菌控制非常重要,从而避免了自体移植的需要,并有助于面部和头部皮肤的快速愈合和完全恢复。

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本文引用的文献

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Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing.污染伤口猪模型中的早期愈合事件:纳米晶银对基质金属蛋白酶、细胞凋亡和愈合的影响
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The rate of re-epithelialization across meshed skin grafts is increased with exposure to silver.网状皮肤移植片的再上皮化速率在接触银的情况下会提高。
Burns. 2002 May;28(3):264-6. doi: 10.1016/s0305-4179(01)00119-x.
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Principles and practices for treatment of cutaneous wounds with cultured skin substitutes.使用培养皮肤替代物治疗皮肤伤口的原则与实践
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Plast Reconstr Surg. 2002 Apr 1;109(4):1266-73. doi: 10.1097/00006534-200204010-00009.
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