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Transition state analysis of model and enzymatic prenylation reactions.

作者信息

Lenevich Stepan, Xu Juhua, Hosokawa Ayako, Cramer Christopher J, Distefano Mark D

机构信息

Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA.

出版信息

J Am Chem Soc. 2007 May 9;129(18):5796-7. doi: 10.1021/ja069119j. Epub 2007 Apr 17.

DOI:10.1021/ja069119j
PMID:17439118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2561324/
Abstract
摘要

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本文引用的文献

1
Measurement of the alpha-secondary kinetic isotope effect for the reaction catalyzed by mammalian protein farnesyltransferase.哺乳动物蛋白质法尼基转移酶催化反应的α-二级动力学同位素效应的测量。
J Am Chem Soc. 2006 Nov 29;128(47):15086-7. doi: 10.1021/ja065838m.
2
Transition state analogue discrimination by related purine nucleoside phosphorylases.相关嘌呤核苷磷酸化酶对过渡态类似物的识别
J Am Chem Soc. 2006 Jun 7;128(22):7126-7. doi: 10.1021/ja061403n.
3
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.与底物复合的CaaX异戊二烯基转移酶的晶体学分析确定了蛋白质底物选择性的规则。
J Mol Biol. 2004 Oct 15;343(2):417-33. doi: 10.1016/j.jmb.2004.08.056.
4
Farnesyltransferase inhibitors as anticancer agents: critical crossroads.法尼基转移酶抑制剂作为抗癌药物：关键转折点。
Curr Opin Drug Discov Devel. 2004 Jul;7(4):478-86.
5
Alkaline phosphatase revisited: hydrolysis of alkyl phosphates.再探碱性磷酸酶：烷基磷酸酯的水解
Biochemistry. 2002 Mar 5;41(9):3207-25. doi: 10.1021/bi012166y.
6
Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase.人源蛋白质香叶基香叶基转移酶催化反应的立体化学分析
Biochemistry. 2001 Apr 3;40(13):3920-30. doi: 10.1021/bi002011a.
7
Mechanistic studies of rat protein farnesyltransferase indicate an associative transition state.大鼠蛋白质法尼基转移酶的机制研究表明存在一种缔合过渡态。
Biochemistry. 2000 Mar 14;39(10):2593-602. doi: 10.1021/bi992356x.
8
Enzymatic transition states and transition state analog design.酶促过渡态与过渡态类似物设计。
Annu Rev Biochem. 1998;67:693-720. doi: 10.1146/annurev.biochem.67.1.693.
9
Protein prenylation: molecular mechanisms and functional consequences.蛋白质异戊二烯化：分子机制与功能后果
Annu Rev Biochem. 1996;65:241-69. doi: 10.1146/annurev.bi.65.070196.001325.
10
A mechanism for posttranslational modifications of proteins by yeast protein farnesyltransferase.酵母蛋白法尼基转移酶对蛋白质进行翻译后修饰的机制。
Proc Natl Acad Sci U S A. 1995 May 23;92(11):5008-11. doi: 10.1073/pnas.92.11.5008.