Bong C-N, Chen S C C, Jong Y-J, Tok T-S, Hsu C-F, Schouten E J, Makombe S D, Yu J K-L, Harries A D
Taiwan Medical Mission, Mzuzu Central Hospital, Mzuzu, Malawi.
Int J Tuberc Lung Dis. 2007 May;11(5):534-8.
Mzuzu Central Hospital, in the northern region of Malawi, which provides free antiretroviral therapy (ART) to human immunodeficiency virus (HIV) infected adults and children, including those with tuberculosis (TB).
To compare outcomes in HIV-infected children who have been started on ART because of 1) active TB, 2) a past history of TB in the last 2 years and 3) a non-TB diagnosis.
Retrospective data collection using ART patient master cards and ART patient registers.
Between July 2004 and September 2006, 439 (11%) children of a total 3908 patients were started on ART. There were 29 with active TB, 56 with a past history of TB in the last 2 years and 354 with a non-TB diagnosis. The three groups were similar in nutritional indices and CD4-lymphocyte percentages. The 6-month probability of survival was 0.86 in the active TB group, 0.94 in the past history of TB group and 0.89 in the non-TB group. 12-month survival probability for the same groups was 0.86, 0.86 and 0.88, respectively.
HIV-infected children with active and previous TB who are started on ART have good outcomes that are similar to those of children started on ART due to a non-TB diagnosis.
位于马拉维北部地区的姆祖祖中心医院，为感染人类免疫缺陷病毒（HIV）的成人和儿童，包括患有结核病（TB）的患者提供免费抗逆转录病毒疗法（ART）。
比较因以下原因开始接受ART治疗的HIV感染儿童的治疗结果：1）活动性结核病，2）过去2年内有结核病病史，3）非结核病诊断。
使用ART患者主卡和ART患者登记册进行回顾性数据收集。
在2004年7月至2006年9月期间，3908名患者中的439名（11%）儿童开始接受ART治疗。其中29名患有活动性结核病，56名在过去2年内有结核病病史，354名诊断为非结核病。三组在营养指标和CD4淋巴细胞百分比方面相似。活动性结核病组6个月生存率为0.86，结核病病史组为0.94，非结核病组为0.89。相同组别的12个月生存率分别为0.86、0.86和0.88。
因活动性结核病和既往结核病而开始接受ART治疗的HIV感染儿童，其治疗结果良好，与因非结核病诊断而开始接受ART治疗的儿童相似。
