Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Int J Hyperthermia. 2010;26(7):612-7. doi: 10.3109/02656736.2010.487194.
Hyperthermia has long been used in combination with radiation for the treatment of superficial malignancies, in part due to its radiosensitising capabilities. Patients who suffer superficial recurrences of breast cancer, be it in their chest wall following mastectomy, or in their breast after breast conservation, typically have poor clinical outcomes. They often develop distant metastatic disease, but one must not overlook the problems associated with an uncontrolled local failure. Morbidity is enormous, and can significantly impair quality of life. There is no accepted standard of care in treating superficial recurrences of breast cancer, particularly in patients that have previously been irradiated. There is a substantial literature regarding the combined use of hyperthermia and radiotherapy for these superficial recurrences. Most of it is retrospective in nature, but there are several larger phase III randomised trials that show an improved rate of clinical complete response in patients treated with both modalities. In this review article, we will highlight the important prospective data that has been published regarding the combined use of hyperthermia and radiation.
热疗长期以来一直与放射治疗联合用于治疗表浅恶性肿瘤，部分原因是其具有放射增敏作用。接受过乳房切除术的胸壁或乳房保留术后的乳腺癌浅表复发的患者，通常临床结局较差。他们往往会发展为远处转移疾病，但人们不应忽视与不受控制的局部失败相关的问题。发病率非常高，会严重影响生活质量。对于接受过放疗的乳腺癌浅表复发患者，特别是对于此类患者，目前尚无公认的治疗标准。有大量关于热疗和放疗联合治疗这些表浅复发的文献。其中大部分是回顾性的，但有几项较大的 III 期随机试验表明，联合使用这两种方法治疗的患者临床完全缓解率有所提高。在这篇综述文章中，我们将重点介绍关于热疗和放疗联合应用的已发表的重要前瞻性数据。
