Humbert Ianessa A, Robbins JoAnne
William S. Middleton Memorial Veterans Hospital, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
Dysphagia. 2007 Jul;22(3):266-75. doi: 10.1007/s00455-007-9080-9. Epub 2007 Apr 18.
Unknowns about the neurophysiology of normal and disordered swallowing have stimulated exciting and important research questions. Previously, these questions were answered using clinical and animal studies. However, recent technologic advances have moved brain-imaging techniques such as functional magnetic resonance imaging (fMRI) to the forefront of swallowing neurophysiology research. This systematic review has summarized the methods and results of studies of swallowing neurophysiology of healthy adults using fMRI. A comprehensive electronic and hand search for original research was conducted, including few search limitations to yield the maximum possible number of relevant studies. The participants, study design, tasks, and brain image acquisition were reviewed and the results indicate that the primary motor and sensory areas were most consistently active in the healthy adult participants across the relevant studies. Other prevalent areas of activation included the anterior cingulate cortex and insular cortex. Review limitations and suggested future directions are also discussed.
正常吞咽和吞咽障碍的神经生理学方面的未知因素激发了令人兴奋且重要的研究问题。以前，这些问题是通过临床和动物研究来解答的。然而，最近的技术进步已将诸如功能磁共振成像（fMRI）等脑成像技术推到了吞咽神经生理学研究的前沿。本系统综述总结了使用fMRI对健康成年人吞咽神经生理学研究的方法和结果。进行了全面的电子和手工检索以查找原始研究，检索限制极少，以尽可能多地获取相关研究。对参与者、研究设计、任务和脑图像采集进行了综述，结果表明在相关研究中，主要运动和感觉区域在健康成年参与者中最常表现出活跃。其他普遍激活的区域包括前扣带回皮质和岛叶皮质。还讨论了综述的局限性和建议的未来方向。
