过继转移至严重联合免疫缺陷小鼠体内的T细胞的强启动。
Strong priming of T cells adoptively transferred into scid mice.
作者信息
Sunshine G H, Jimmo B L, Ianelli C, Jarvis L
机构信息
Department of Surgery, Tufts University School of Veterinary Medicine, Boston, Massachusetts.
出版信息
J Exp Med. 1991 Dec 1;174(6):1653-6. doi: 10.1084/jem.174.6.1653.
Abstract
We have examined the requirements for activating unprimed T cells in vivo by transferring T cells into scid mice, which lack mature B and T cells. Purified adult thymocytes and a protein antigen, keyhole limpet hemocyanin (KLH), were injected into scid mice. scid mice injected with T cells and KLH developed cellular lymph nodes containing CD4+ and CD8+ T cells. Cells recovered from the lymph nodes of injected scid mice proliferated and secreted interleukin 2 in response to KLH in vitro. The results indicate that T cells can be primed to KLH in the scid mouse in the absence of B cells.
摘要
我们通过将T细胞转移到缺乏成熟B细胞和T细胞的scid小鼠体内，研究了在体内激活未致敏T细胞的条件。将纯化的成年胸腺细胞和一种蛋白质抗原——钥孔戚血蓝蛋白（KLH）注射到scid小鼠体内。注射了T细胞和KLH的scid小鼠形成了含有CD4+和CD8+ T细胞的细胞性淋巴结。从注射后的scid小鼠淋巴结中回收的细胞在体外对KLH产生增殖反应并分泌白细胞介素2。结果表明，在没有B细胞的情况下，scid小鼠体内的T细胞可以被KLH致敏。
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