Ogur Recai, Uysal Bulent, Ogur Torel, Yaman Halil, Oztas Emin, Ozdemir Aysegul, Hasde Metin
Department of Environmental Health, Gulhane Medical Faculty, Ankara, Turkey.
Basic Clin Pharmacol Toxicol. 2007 May;100(5):334-8. doi: 10.1111/j.1742-7843.2007.00053.x.
The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as they wanted. Groups 3 and 4, consisting of five rats each, received only rat chow and water. The bone mineral density of the rats was measured using dual energy X-ray absorptiometry at the end of 30 days. The blood values and weights of the animals were also determined. The oesophagus and kidneys were removed for histopathological examination. The weight gain was higher in the groups consuming cola drinks than the control group rats (P < 0.05). Water consumption decreased 5.9 times while total fluid consumption increased 1.6-1.9 times in the group consuming cola drinks. No significant change was detected in the blood calcium levels. There was a significant decrease in the bone mineral density of test groups when compared to the control groups (P < 0.05). While we did not detect any pathological oesophageal changes in the rats consuming cola drinks, examination of the kidneys revealed general glomerular congestion and intertubular bleeding. We suggest that the decrease in bone mineral density might be related to the renal damage caused by cola drinks in addition to other related factors.
本研究的目的是确定饮用可乐饮料引起的骨矿物质密度变化及相关因素。将30只斯普拉格-道利大鼠分为四组。第1组和第2组分别由10只雄性和10只雌性大鼠组成，给予它们想吃的食物、水和可乐饮料。第3组和第4组每组各有5只大鼠，仅给予大鼠饲料和水。在30天结束时，使用双能X线吸收法测量大鼠的骨矿物质密度。还测定了动物的血液值和体重。取出食管和肾脏进行组织病理学检查。饮用可乐饮料的组体重增加高于对照组大鼠（P<0.05）。饮用可乐饮料的组水消耗量减少了5.9倍，而总液体消耗量增加了1.6 - 1.9倍。血钙水平未检测到显著变化。与对照组相比，试验组的骨矿物质密度显著降低（P<0.05）。虽然在饮用可乐饮料的大鼠中未检测到任何病理性食管变化，但对肾脏的检查显示普遍存在肾小球充血和肾小管间出血。我们认为，除其他相关因素外，骨矿物质密度的降低可能与可乐饮料引起的肾损伤有关。
