低剂量肉毒杆菌毒素治疗痉挛性斜颈。
Low dose botulinum toxin in spasmodic torticollis.
作者信息
D'Costa D F, Abbott R J
机构信息
Department of Neurology, Leicester Royal Infirmary.
出版信息
J R Soc Med. 1991 Nov;84(11):650-1. doi: 10.1177/014107689108401107.
Botulinum toxin has been successfully used to treat spasmodic torticollis. The optimum dosage is not clear and the recommended doses in the United Kingdom are 20-25 ng. We have used much lower doses (average 13 ng) without loss of efficacy and accompanied by a reduction in side effects. We treated 12 patients (eight women and four men) with a mean duration of torticollis of 4 years. Eleven of the 12 patients (91%) showed an improvement in total scores for pain and degree of head movement. The benefits appeared a week after treatment and lasted for 3 months. Side effects were minimal and transient. Our experience suggests low doses of the toxin may be equally efficacious.
肉毒杆菌毒素已成功用于治疗痉挛性斜颈。最佳剂量尚不清楚，英国推荐的剂量为20 - 25纳克。我们使用了低得多的剂量（平均13纳克），疗效未减，且副作用有所减少。我们治疗了12例患者（8名女性和4名男性），斜颈平均持续时间为4年。12例患者中有11例（91%）疼痛总分和头部活动程度有所改善。治疗一周后出现疗效，持续3个月。副作用轻微且短暂。我们的经验表明低剂量毒素可能同样有效。
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