Carroll I Dale, Toovey Stephen, Van Gompel Alfons
The Pregnant Traveler, 4475 Wilson Ave., SW, Suite 8, Grandville, MI 49418, USA.
Travel Med Infect Dis. 2007 May;5(3):183-8. doi: 10.1016/j.tmaid.2006.11.002. Epub 2007 Jan 5.
The increasing incidence of dengue with the concomitant rise in travel during pregnancy makes it likely that a pregnant woman will plan travel to or present after travel to endemic areas.
Literature search and communication with researchers.
Case reports of dengue during pregnancy, the peripartum period and neonatal dengue were found. There is little systematic research.
Pregnancy appears not to increase the incidence or severity of dengue, but some case reports suggest that dengue may predispose to certain pregnancy complications. Transplacental infection occurs, but protective antibodies pass transplacentally and fetal effects may be minimal given sufficient immune response. In near-term disease, severe fetal or neonatal illness and death may occur. Such illness may also predispose the newborn to subsequent dengue hemorrhagic fever. Clinicians should be aware that presentation in either maternal or neonatal disease may be atypical and confound diagnosis. Women in late pregnancy should avoid travel to areas of ongoing disease, and those earlier in pregnancy should consider dengue a serious hazard. If travel is unavoidable, mosquito avoidance measures are mandated. If a woman acquires dengue fever while pregnant, conservative medical and obstetrical management are the treatments of choice. Further research is required.
随着登革热发病率的上升以及孕期旅行的增加，孕妇前往流行地区旅行或旅行后出现症状的可能性增大。
文献检索及与研究人员交流。
发现了孕期、围产期登革热及新生儿登革热的病例报告。系统性研究较少。
妊娠似乎不会增加登革热的发病率或严重程度，但一些病例报告表明登革热可能易引发某些妊娠并发症。存在经胎盘感染，但保护性抗体可经胎盘传递，若有足够的免疫反应，对胎儿的影响可能极小。在临近足月发病时，可能会发生严重的胎儿或新生儿疾病及死亡。此类疾病也可能使新生儿易患随后的登革出血热。临床医生应意识到，孕产妇或新生儿疾病的表现可能不典型，会混淆诊断。妊娠晚期妇女应避免前往疾病流行地区，妊娠早期妇女应将登革热视为严重危害。如果旅行不可避免，必须采取防蚊措施。如果孕妇感染登革热，保守的医学及产科处理是首选治疗方法。需要进一步研究。
