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本文引用的文献

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Diagnosis of invasive candidiasis by enzyme-linked immunosorbent assay using the N-terminal fragment of Candida albicans hyphal wall protein 1.使用白色念珠菌菌丝壁蛋白1的N端片段通过酶联免疫吸附测定法诊断侵袭性念珠菌病。
BMC Microbiol. 2007 Apr 21;7:35. doi: 10.1186/1471-2180-7-35.
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A fungicidal monoclonal antibody protects against murine invasive candidiasis.一种杀真菌单克隆抗体可预防小鼠侵袭性念珠菌病。
Infect Immun. 2006 May;74(5):3042-5. doi: 10.1128/IAI.74.5.3042-3045.2006.
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The anti-Candida albicans vaccine composed of the recombinant N terminus of Als1p reduces fungal burden and improves survival in both immunocompetent and immunocompromised mice.由Als1p重组N端组成的抗白色念珠菌疫苗可减轻免疫功能正常和免疫功能低下小鼠的真菌负荷并提高其存活率。
Infect Immun. 2005 Sep;73(9):6191-3. doi: 10.1128/IAI.73.9.6191-6193.2005.
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Antifungal and antitumor activities of a monoclonal antibody directed against a stress mannoprotein of Candida albicans.一种针对白色念珠菌应激甘露糖蛋白的单克隆抗体的抗真菌和抗肿瘤活性
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Functional analysis of the Candida albicans ALS1 gene product.白色念珠菌ALS1基因产物的功能分析
Yeast. 2004 Apr 30;21(6):473-82. doi: 10.1002/yea.1111.
6
A monoclonal antibody directed against a Candida albicans cell wall mannoprotein exerts three anti-C. albicans activities.一种针对白色念珠菌细胞壁甘露糖蛋白的单克隆抗体具有三种抗白色念珠菌活性。
Infect Immun. 2003 Sep;71(9):5273-9. doi: 10.1128/IAI.71.9.5273-5279.2003.
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The ALS gene family of Candida albicans.白色念珠菌的肌萎缩侧索硬化症基因家族。
Trends Microbiol. 2001 Apr;9(4):176-80. doi: 10.1016/s0966-842x(01)01984-9.
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Identification of Candida albicans ALS2 and ALS4 and localization of als proteins to the fungal cell surface.白色念珠菌ALS2和ALS4的鉴定以及als蛋白在真菌细胞表面的定位。
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Heat-shock mannoproteins as targets of secretory IgA in Candida albicans.热休克甘露糖蛋白作为白色念珠菌中分泌型IgA的靶标
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Analysis of cell wall extracts of Candida albicans by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blot techniques.采用十二烷基硫酸钠-聚丙烯酰胺凝胶电泳和蛋白质印迹技术对白色念珠菌的细胞壁提取物进行分析。
Infect Immun. 1986 Sep;53(3):565-72. doi: 10.1128/iai.53.3.565-572.1986.

杀真菌单克隆抗体C7与白色念珠菌Als3结合。

Fungicidal monoclonal antibody C7 binds to Candida albicans Als3.

作者信息

Brena Sonia, Omaetxebarría Miren J, Elguezabal Natalia, Cabezas Jonathan, Moragues María D, Pontón José

机构信息

Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain.

出版信息

Infect Immun. 2007 Jul;75(7):3680-2. doi: 10.1128/IAI.01840-06. Epub 2007 Apr 23.

DOI:10.1128/IAI.01840-06
PMID:17452471
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1932956/
Abstract

Monoclonal antibody (MAb) C7 reacted with a >200-kDa component from the Candida albicans cell wall identified by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry as Als3. It also bound the recombinant N terminus of Als3. Binding of MAb C7 to Als3 may explain the biological activities exerted by the MAb on C. albicans.

摘要

单克隆抗体（MAb）C7与白色念珠菌细胞壁中一种分子量大于200 kDa的成分发生反应，经基质辅助激光解吸电离飞行时间质谱鉴定为Als3。它还与Als3的重组N端结合。MAb C7与Als3的结合可能解释了该单克隆抗体对白色念珠菌发挥的生物学活性。