Stegmann G F, Jago M
Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
J S Afr Vet Assoc. 2006 Dec;77(4):205-9. doi: 10.4102/jsava.v77i4.378.
Captive cheetah (Acinonyx jubatus) scheduled for either general health examination or dental surgery were immobilised with combinations of medetomidine-ketamine (K/DET, n = 19), midazolam-ketamine (K/MID, n = 4) or medetomidine-tiletamine-zolazepam (Z/DET, n = 5). Induction time and arterial blood pressure was not statistically significantly (P > 0.05) different between treatment groups. Transient seizures were observed in the K/DET treated animals during induction. Hypertension was present in all groups during anaesthesia with mean (+/- SD) systolic pressure of 30.7 +/- 5.0 kPa for the K/DET group, 27.7 +/- 2.7 kPa for the K/MID group, and 33.1 +/- 4.6 kPa for the Z/DET group. Heart rate was statistically significantly (P < 0.05) lower in the K/DET group (69 +/- 13.2 beats/min) compared to the K/MID group (97 +/- 22.6 beats/min), and ventilation rate was statistically significantly (P < 0.05) lower in the K/MID group (15 +/- 0.0 breaths/min) compared with the K/DET group (21 +/- 4.6). A metabolic acidosis and hypoxia were observed during anaesthesia when breathing air. Oxygen (O2) administration resulted in a statistically significant (P < 0.05) increase in the arterial partial pressure of carbon dioxide (hypercapnoea), arterial partial pressure of O2, and % oxyhaemoglobin saturation.
计划进行常规健康检查或牙科手术的圈养猎豹（猎豹属），分别使用美托咪定 - 氯胺酮组合（K/DET，n = 19）、咪达唑仑 - 氯胺酮组合（K/MID，n = 4）或美托咪定 - 替来他明 - 唑拉西泮组合（Z/DET，n = 5）进行麻醉。各治疗组之间的诱导时间和动脉血压差异无统计学意义（P > 0.05）。在诱导过程中，K/DET治疗的动物出现了短暂性癫痫发作。所有组在麻醉期间均出现高血压，K/DET组平均（±标准差）收缩压为30.7 ± 5.0 kPa，K/MID组为27.7 ± 2.7 kPa，Z/DET组为33.1 ± 4.6 kPa。与K/MID组（97 ± 22.6次/分钟）相比，K/DET组心率显著降低（P < 0.05）（69 ± 13.2次/分钟）；与K/DET组（21 ± 4.6次/分钟）相比，K/MID组呼吸频率显著降低（P < 0.05）（15 ± 0.0次/分钟）。在吸入空气麻醉期间观察到代谢性酸中毒和低氧血症。给予氧气（O2）后，动脉二氧化碳分压（高碳酸血症）、动脉氧分压和氧合血红蛋白饱和度百分比均有统计学显著升高（P < 0.05）。
