Yamamoto Shingo
The Department of Urology, Hyogo College of Medicine, 1-1 Mukogawacho, Nishinomiya, Hyogo 663-8501, Japan.
J Infect Chemother. 2007 Apr;13(2):68-73. doi: 10.1007/s10156-007-0506-y. Epub 2007 May 8.
Escherichia coli is the most common cause of complicated as well as uncomplicated urinary tract infections (UTIs). Most of these uropathogenic E. coli (UPEC) strains exhibit certain virulence factors (VFs), including adhesins, iron uptake systems, synthesis of cytotoxins, and specific O:K:H serotypes. Molecular epidemiological studies of UPEC have contributed to the discovery of uropathogenic VFs, to an understanding of the pathogenesis of UTIs as ascending infections, and to the clarification of genetic linkages between different virulence genes such as pathogenicity islands (PAIs), which are one of the mechanisms for horizontal VF gene transfers between the same or related species. Uropathogenic VFs not only play an important role individually but also work cooperatively in a fine-tuned manner with coordinated regulation and expression.
大肠杆菌是复杂性和非复杂性尿路感染（UTIs）最常见的病因。大多数这些尿路致病性大肠杆菌（UPEC）菌株表现出某些毒力因子（VFs），包括黏附素、铁摄取系统、细胞毒素合成以及特定的O:K:H血清型。UPEC的分子流行病学研究有助于发现尿路致病性VFs，理解UTIs作为上行性感染的发病机制，并阐明不同毒力基因之间的遗传联系，如致病岛（PAIs），这是同一或相关物种之间水平VF基因转移的机制之一。尿路致病性VFs不仅各自发挥重要作用，而且还通过协调调控和表达以微调的方式协同工作。
