多模态磁共振成像对2型糖尿病患者的动脉粥样硬化和血管功能障碍进行量化。
Multi-modal magnetic resonance imaging quantifies atherosclerosis and vascular dysfunction in patients with type 2 diabetes mellitus.
作者信息
Lee Justin M S, Shirodaria Cheerag, Jackson Clare E, Robson Matthew D, Antoniades Charalambos, Francis Jane M, Wiesmann Frank, Channon Keith M, Neubauer Stefan, Choudhury Robin P
机构信息
Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.
出版信息
Diab Vasc Dis Res. 2007 Mar;4(1):44-8. doi: 10.3132/dvdr.2007.005.
Abstract
Vascular magnetic resonance imaging (MRI) is emerging as a powerful research tool. We studied 18 patients with type 2 diabetes mellitus and 20 controls (all with coronary artery disease). MRI measured distensibility, pulse wave velocity (PWV) and atherosclerosis in the aorta, and brachial artery flow-mediated dilatation (FMD). Patients with diabetes showed lower aortic distensibility (2.1 x 10(-3) vs . 3.5 x 10(-3) mmHg-1, p<0.01), faster PWV (8.8 vs ., 6.2 m/s, p<0.01) and impaired FMD (8.5% vs . 13.8%, p<0.05). Diabetes was an independent negative predictor of distensibility. Aortic atherosclerosis was similar in the two groups. There was a negative correlation between aortic distensibility and atherosclerosis in control subjects only, suggesting that other factors such as protein cross-linking may explain lower aortic distensibility in diabetes. MRI provides comprehensive vascular phenotyping in patients with type 2 diabetes and is likely to be useful in studies of disease progression and drug therapy.
摘要
血管磁共振成像（MRI）正在成为一种强大的研究工具。我们研究了18例2型糖尿病患者和20名对照者（均患有冠状动脉疾病）。MRI测量了主动脉的扩张性、脉搏波速度（PWV）和动脉粥样硬化，以及肱动脉血流介导的扩张（FMD）。糖尿病患者的主动脉扩张性较低（2.1×10⁻³ 对比3.5×10⁻³ mmHg⁻¹，p<0.01），PWV较快（8.8对比6.2 m/s，p<0.01），FMD受损（8.5%对比13.8%，p<0.05）。糖尿病是扩张性的独立负性预测因子。两组的主动脉粥样硬化情况相似。仅在对照者中，主动脉扩张性与动脉粥样硬化呈负相关，这表明诸如蛋白质交联等其他因素可能解释了糖尿病患者主动脉扩张性较低的原因。MRI为2型糖尿病患者提供了全面的血管表型分析，可能有助于疾病进展和药物治疗的研究。
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