Plestina-Borjan Ivna, Klinger-Lasić Mery
Department of Ophthalmology, Split University School of Medicine, Split, Croatia.
Coll Antropol. 2007 Jan;31 Suppl 1:33-8.
A clinical epidemiological study has been conducted as apart of research project investigating chronic exposure to solar ultraviolet radiation (UVR) as a factor contributing to the onset of age-related macular degeneration (ARMD). The study included 623 subjects older than 50 from two different geographic areas, one with high solar radiation (the island of Solta - Region 1) and the other (Zagreb and its surroundings - Region 2) with low solar radiation. Individual exposure to UVR was assessed according to global exposure to sunlight, on the basis detailed history of life-long exposure to sunlight, with special reference to professional history and geophysical specificities of the respective areas. Different grades of ARMD were based on the fundus photographs and flourescein angiography. Statistically significant relation was found between ARMD and mean daily exposure (in hours) to solar radiation in Region 1 (chi2 = 186.22; p = 0.000), Region 2 (chi2 = 25.66; p = 0.000) and in both regions together (chi2 = 216.43; p = 0.000). ARMD is more frequent in the subjects belonging to the Region 1 and with the same exposure to sunlight (8 hours and more) which goes in favor of their increased UVR exposure. The results support a relationship between long-term sunlight exposure and increased risk of ARMD.
作为一项研究项目的一部分，开展了一项临床流行病学研究，该项目旨在调查长期暴露于太阳紫外线辐射（UVR）作为导致年龄相关性黄斑变性（ARMD）发病的一个因素。该研究纳入了来自两个不同地理区域的623名50岁以上的受试者，一个区域太阳辐射高（索尔塔岛 - 地区1），另一个区域（萨格勒布及其周边地区 - 地区2）太阳辐射低。根据全球阳光暴露情况，基于详细的终生阳光暴露史，特别是参考各地区的职业史和地球物理特性，评估个体对UVR的暴露情况。不同等级的ARMD基于眼底照片和荧光素血管造影。在地区1（χ2 = 186.22；p = 0.000）、地区2（χ2 = 25.66；p = 0.000）以及两个地区合并（χ2 = 216.43；p = 0.000）中，均发现ARMD与太阳辐射的平均每日暴露时长（小时）之间存在统计学显著关系。在地区1且阳光暴露相同（8小时及以上）的受试者中，ARMD更为常见，这有利于证明他们的UVR暴露增加。结果支持长期阳光暴露与ARMD风险增加之间存在关联。
