Zhou Hongjie, Zhang Huina, Yu Aiqing, Xie Jiajun
Hangzhou Hospital for the Prevention and Treatment of Occupational Diseases, Zhejiang, Hangzhou, China.
Department of Ophthalmology, College of Medicine, the 2nd Affiliated Hospital of Zhejiang University, Zhejiang, Hangzhou, China.
BMC Ophthalmol. 2018 Dec 20;18(1):331. doi: 10.1186/s12886-018-1004-y.
A substantial number of epidemiological studies have investigated the possible associations between sunlight exposure and Age-related Macular Degeneration (AMD), but the results from studies are inconsistent. The aim of this meta-analysis was to evaluate the association between sunlight exposure and the risk of AMD.
Relevant studies were searched using databases including PubMed, EMBASE, and Web of Science database. Two authors independently extracted data and assessed study quality. The random-effects model was used to calculate the pooled covariates-adjusted odds ratio (OR). Subgroup analyses based on study design, stage of AMD, method of exposure assessment, and study latitude were carried out. The heterogeneity across the studies was tested, as was publication bias.
Fourteen eligible studies including 43,934 individuals based on the inclusion criteria were analyzed. The pooled OR for sunlight exposure and AMD was 1.10 (95% CI = 0.98-1.23). In addition, similar insignificant results were observed in further subgroup analyses based on stage of AMD, method of exposure assessment, and study latitude. Sun-avoidance behavior did not decrease the risk of AMD (OR = 1.12, 95% CI = 0.76-1.67). Moderate heterogeneity was observed in most of analyses.
The results indicate that sunlight exposure may not be associated with increased risk of AMD based on current published data.
大量流行病学研究调查了阳光暴露与年龄相关性黄斑变性（AMD）之间可能存在的关联，但研究结果并不一致。本荟萃分析的目的是评估阳光暴露与AMD风险之间的关联。
使用包括PubMed、EMBASE和科学网数据库在内的数据库检索相关研究。两位作者独立提取数据并评估研究质量。采用随机效应模型计算合并的协变量调整比值比（OR）。基于研究设计、AMD阶段、暴露评估方法和研究纬度进行亚组分析。检验了研究间的异质性以及发表偏倚。
根据纳入标准，分析了14项符合条件的研究，共43934名个体。阳光暴露与AMD的合并OR为1.10（95%CI=0.98-1.23）。此外，在基于AMD阶段、暴露评估方法和研究纬度的进一步亚组分析中，也观察到了类似的无显著意义的结果。避免阳光照射的行为并未降低AMD风险（OR=1.12，95%CI=0.76-1.67）。大多数分析中观察到中度异质性。
结果表明，根据目前已发表的数据，阳光暴露可能与AMD风险增加无关。
