McCarthy G M, Barthelemy C R, Veum J A, Wortmann R L
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
Arthritis Rheum. 1991 Dec;34(12):1489-94. doi: 10.1002/art.1780341203.
Ten years ago, we studied the clinical and radiographic manifestations of gout in 60 patients and described 3 patterns of disease. To determine the consequences of management over a 10-year period, we recently reassessed the 39 available patients of this population. We found that although reduced tophaceous deposition on physical examination correlated with normalization of the serum urate concentration, no correlation existed between radiographic changes and mean serum urate concentrations. Progression of gouty changes on radiography reflected progressive deformity on physical examination. We have described the radiographic changes that occurred in a well-characterized population of subjects with gout over 10 years and determined that serum urate concentrations alone may not provide an effective means of monitoring the progression of tophaceous disease in bone.
十年前，我们研究了60例痛风患者的临床和影像学表现，并描述了3种疾病模式。为了确定10年期间治疗的效果，我们最近重新评估了该人群中39例可联系到的患者。我们发现，虽然体格检查中痛风石沉积的减少与血清尿酸盐浓度的正常化相关，但影像学改变与平均血清尿酸盐浓度之间不存在相关性。X线片上痛风改变的进展反映了体格检查中渐进性畸形。我们描述了在一组特征明确的痛风患者人群中10年间发生的影像学改变，并确定仅血清尿酸盐浓度可能无法提供监测骨骼中痛风石疾病进展的有效方法。
