Nybo Mads, Friis-Hansen Lennart, Felding Peter, Milman Nils
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Ann Hematol. 2007 Sep;86(9):647-51. doi: 10.1007/s00277-007-0305-7. Epub 2007 May 5.
The aim of the study was to investigate whether the well-known high anemia prevalence in pregnant women from the eastern Mediterranean and Asian regions decreased when the women immigrated to a low-frequency region (Denmark). During 70 months, 1,741 pregnant immigrant women referred from primary care to an obligatory hemoglobinopathy screening were eligible for the study, as their screening was negative. To compare this group with a cohort of 205 pregnant ethnic Danish women, the groups were matched by gestational age, and a total of 406 immigrant women were included. Hemoglobin (Hb) and iron status parameters were examined in the two groups. The prevalence of anemia was higher in the immigrant group (20.0%) compared to the Danish women (4.9%) (P < 0.0001). Blood Hb concentration was 119 +/- 12 g/l (mean +/- SD) in the immigrant group compared to 122 +/- 9 g/l in the Danish group (P = 0.01). Erythrocyte mean corpuscular volume (MCV) was also lower in the immigrant group (87 +/- 7 fl vs 96 +/- 4 fl) (P < 0.0001). A total of 13.1% of the immigrant women had an MCV <80 fl (the lower reference limit) compared to 0.0% in the Danish group, and plasma iron, ferritin, and transferrin saturation values indicated iron deficiency. Conclusively, the pregnant immigrant women had significantly higher prevalence of anemia compared to pregnant women of Danish origin. It indicates the need for an alternative routine screening procedure for this population group, which should also include nutritional counselling.
该研究的目的是调查东地中海和亚洲地区孕妇中广为人知的高贫血患病率在这些女性移民到低频地区（丹麦）后是否会降低。在70个月期间，1741名从初级保健机构转诊来进行强制性血红蛋白病筛查的怀孕移民女性符合该研究的条件，因为她们的筛查结果为阴性。为了将该组与205名丹麦裔怀孕女性组成的队列进行比较，两组按孕周进行匹配，共纳入406名移民女性。对两组的血红蛋白（Hb）和铁状态参数进行了检查。移民组的贫血患病率（20.0%）高于丹麦女性（4.9%）（P<0.0001）。移民组的血液Hb浓度为119±12g/l（平均值±标准差），而丹麦组为122±9g/l（P=0.01）。移民组的红细胞平均体积（MCV）也较低（87±7fl对96±4fl）（P<0.0001）。共有13.1%的移民女性MCV<80fl（参考下限），而丹麦组为0.0%，血浆铁、铁蛋白和转铁蛋白饱和度值表明存在缺铁。总之，与丹麦裔孕妇相比，怀孕移民女性的贫血患病率显著更高。这表明需要为这一人群制定替代的常规筛查程序，该程序还应包括营养咨询。
