Abbas Fawkeya A, Al-Massarany Shaza M, Khan Shabana, Al-Howiriny Tawfeq A, Mossa Jaber S, Abourashed Ehab A
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Nat Prod Res. 2007 May;21(5):383-91. doi: 10.1080/14786410600942025.
The aerial part of Commiphora opobalsamum L. (Burseraceae) growing in Saudi Arabia was subjected to a phytopharmacological investigation in order to identify its major chemical constituents and to evaluate its extracts and isolated compounds in preliminary in vitro assays for antimicrobial, antimalarial, antitumor, anti-inflammatory (COX-2 inhibition), antioxidant and estrogenic activity. Six compounds were isolated and identified as the triterpenes friedelin, canophyllal, and oleanonic acid; the flavonols mearnsetin and quercetin; and syringic acid. The ethyl acetate extract was moderately active against Staphylococcus aureus, Pseudomonas aeruginosa, and Plasmodium falciparum; while the petroleum ether and chloroform extracts inhibited COX-2 at 5 and 10 microg mL(-1), respectively. Of the isolated compounds, syringic acid showed moderate antimalarial, anticandidal, and antimycobacterial activity; while mearnsetin and quercetin exhibited antioxidant activity comparable to ascorbic acid and trolox. This is the first detailed phytochemical investigation of C. opobalsamum L. growing in Saudi Arabia and elsewhere. The isolated compounds are reported from this plant for the first time and their full (1)H and (13)C NMR assignments are included.
对生长在沙特阿拉伯的没药树（橄榄科）地上部分进行了植物药理学研究，以确定其主要化学成分，并在初步体外试验中评估其提取物和分离出的化合物的抗菌、抗疟、抗肿瘤、抗炎（COX - 2抑制）、抗氧化和雌激素活性。分离并鉴定出六种化合物，分别为三萜类化合物木栓酮、香树素和齐墩果酸；黄酮醇山姜素和槲皮素；以及丁香酸。乙酸乙酯提取物对金黄色葡萄球菌、铜绿假单胞菌和恶性疟原虫有中等活性；而石油醚和氯仿提取物分别在5和10μg mL(-1)时抑制COX - 2。在分离出的化合物中，丁香酸显示出中等的抗疟、抗念珠菌和抗分枝杆菌活性；而山姜素和槲皮素表现出与抗坏血酸和生育三烯酚相当的抗氧化活性。这是对生长在沙特阿拉伯及其他地区的没药树首次进行的详细植物化学研究。首次报道了从该植物中分离出的化合物，并给出了它们完整的(1)H和(13)C NMR归属。
