Pharmacological and Diagnostic Research Center, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Pharmacological and Diagnostic Research Center, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.
Molecules. 2023 Mar 2;28(5):2321. doi: 10.3390/molecules28052321.
The use of the synthetic drugs has increased in the last few decades; however, these drugs exhibit various side effects. Scientists are therefore seeking alternatives from natural sources. has long been used to treat various disorders. It is commonly known as bisham or balm of Makkah. This plant contains various phytochemicals, including polyphenols and flavonoids, with biological potential. We found that steam-distilled essential oil of exhibited higher antioxidant activity (IC 22.2 µg/mL) than ascorbic acid (IC 1.25 µg/mL). The major constituents (>2%) in the essential oil were β-myrcene, nonane, verticiol, β-phellandrene, β-cadinene, terpinen-4-ol, β-eudesmol, α-pinene, cis-β-copaene and verticillol, which might be responsible for the antioxidant and antimicrobial activity against Gram-positive bacteria. The extract of exhibited inhibitory activity against cyclooxygenase (IC 450.1 µg/mL), xanthine oxidase (251.2 µg/mL) and protein denaturation (110.5 µg/mL) compared to standard treatments, making it a viable treatment from a natural plant source. LC-MS analysis revealed the presence of phenolic compounds such as caffeic acid phenyl ester, hesperetin, hesperidin, chrysin and transient amounts of catechin, gallic acid, rutin and caffeic acid. The chemical constituents of this plant can be explored further to investigate its wide variety of therapeutic potential.
在过去的几十年中，合成药物的使用有所增加；然而，这些药物表现出各种副作用。因此，科学家们正在从天然来源中寻找替代品。 长期以来一直被用于治疗各种疾病。它通常被称为bisham 或麦加香膏。这种植物含有各种具有生物潜力的植物化学物质，包括多酚和类黄酮。我们发现， 的蒸汽蒸馏精油表现出比抗坏血酸（IC 22.2 µg/mL）更高的抗氧化活性（IC 22.2 µg/mL）。精油中的主要成分（>2%）为β-月桂烯、壬烷、 verticiol、β-蒎烯、β-杜松烯、萜品-4-醇、β-桉叶醇、α-蒎烯、顺式-β-古芸烯和 verticillol，它们可能是抗氧化和抗革兰氏阳性菌的抗菌活性的原因。 提取物对环加氧酶（IC 450.1 µg/mL）、黄嘌呤氧化酶（251.2 µg/mL）和蛋白质变性（110.5 µg/mL）具有抑制活性，与标准治疗相比，这使其成为一种可行的天然植物来源治疗方法。LC-MS 分析显示存在酚类化合物，如咖啡酸苯酯、橙皮素、橙皮苷、白杨素和瞬态儿茶素、没食子酸、芦丁和咖啡酸。可以进一步探索这种植物的化学成分，以研究其广泛的治疗潜力。
