Shmuely Haim, Yahav Jacob, Samra Zmira, Chodick Gabriel, Koren Rivka, Niv Yaron, Ofek Itzhak
Helicobacter pylori Research Institute, Rabin Medical Center, Beilinson Campus, Petah Tikva, Tel Aviv University, Tel Aviv, Israel.
Mol Nutr Food Res. 2007 Jun;51(6):746-51. doi: 10.1002/mnfr.200600281.
Cranberry constituents are known to exert anti-adhesion activity on H. pylori in vitro. To determine their possible additive effect to triple therapy with omeprazole, amoxicillin and clarithromycin (OAC), a double-blind randomized clinical study was carried out. One-hundred-seventy-seven patients with H. pylori infection treated with OAC for 1 week were randomly allocated to receive 250 mL of either cranberry juice (cranberry-OAC, n = 89) or placebo beverage (placebo-OAC, n = 88) twice daily and only cranberry juice or placebo beverage for the next 2 weeks. Treatment outcome was determined with the(13)C urea breath test ((13)C-UBT). An additional control group consisted of patients referred to the same center during the same period who were treated with OAC alone for 1 week (non-placebo-OAC, n = 712). Overall, the rate of H. pylori eradication ((13)C-UBT < 3.5) was 82.5%, with no statistically significant difference among the three arms. Analysis by gender revealed that for female subjects, the eradication rate was higher in the cranberry-OAC arm (n = 42, 95.2%) than in the placebo-OAC arm (n = 53, 86.8%) and significantly higher than in the non-placebo-OAC group (n = 425, 80%; p = 0.03). For males, the rate was nonsignificantly lower in the cranberry-OAC arm (n = 35, 73.9%) than in the placebo-OAC arm (n = 45, 80.0%) and non-placebo-OAC group (n = 287, 85.0%). These results suggest that the addition of cranberry to triple therapy improves the rate of H. pylori eradication in females.
已知蔓越莓成分在体外对幽门螺杆菌具有抗黏附活性。为确定其对奥美拉唑、阿莫西林和克拉霉素三联疗法（OAC）可能的增效作用，开展了一项双盲随机临床研究。177例接受OAC治疗1周的幽门螺杆菌感染患者被随机分配，每天两次接受250 mL蔓越莓汁（蔓越莓-OAC组，n = 89）或安慰剂饮料（安慰剂-OAC组，n = 88），并在接下来的2周仅饮用蔓越莓汁或安慰剂饮料。采用¹³C尿素呼气试验（¹³C-UBT）确定治疗结果。另一个对照组由同期转诊至同一中心、仅接受OAC治疗1周的患者组成（非安慰剂-OAC组，n = 712）。总体而言，幽门螺杆菌根除率（¹³C-UBT < 3.5）为82.5%，三组之间无统计学显著差异。按性别分析显示，对于女性受试者，蔓越莓-OAC组（n = 42，95.2%）的根除率高于安慰剂-OAC组（n = 53，86.8%），且显著高于非安慰剂-OAC组（n = 425，80%；p = 0.03）。对于男性，蔓越莓-OAC组（n = 35，73.9%）的根除率略低于安慰剂-OAC组（n = 45，80.0%）和非安慰剂-OAC组（n = 287，85.0%），但差异无统计学意义。这些结果表明，三联疗法中添加蔓越莓可提高女性幽门螺杆菌的根除率。
