Beulens J W J, van Loon L J C, Kok F J, Pelsers M, Bobbert T, Spranger J, Helander A, Hendriks H F J
TNO Quality of Life, Business Unit Biosciences, Utrechtseweg 48, 3704 HE Zeist, P.O. Box 360, 3700 AJ, Zeist, The Netherlands.
Diabetologia. 2007 Jul;50(7):1388-92. doi: 10.1007/s00125-007-0699-8. Epub 2007 May 11.
AIMS/HYPOTHESIS: The aim of this study was to investigate whether moderate alcohol consumption increases plasma high molecular weight (HMW) adiponectin and/or muscle oxidative capacity.
Eleven lean (BMI 18-25 kg/m(2)) and eight overweight (BMI >or=27 kg/m(2)) men consumed 100 ml whisky ( approximately 32 g alcohol) or water daily for 4 weeks in a randomised, controlled, crossover trial. After each treatment period, muscle biopsies and fasting blood samples were collected.
Adiponectin concentrations increased (p < 0.001) by 12.5% after 4 weeks of moderate alcohol consumption. Moderate alcohol consumption tended to increase HMW adiponectin by 57% (p = 0.07) and medium molecular weight adiponectin by 12.5% (p = 0.07), but not low molecular weight (LMW) adiponectin. Skeletal muscle citrate synthase, cytochrome c oxidase and beta-3-hydroxyacyl coenzyme A dehydrogenase (beta-HAD) activity were not changed after moderate alcohol consumption, but an interaction between alcohol consumption and BMI was observed for cytochrome c oxidase (p = 0.072) and citrate synthase (p = 0.102) activity. Among lean men, moderate alcohol consumption tended to increase cytochrome c oxidase (p = 0.08) and citrate synthase activity (p = 0.12) by 23 and 26%, respectively, but not among overweight men. In particular, plasma HMW adiponectin correlated positively with activities of skeletal muscle citrate synthase (r = 0.64, p = 0.009), cytochrome c oxidase (p = 0.59, p = 0.009) and beta-HAD (r = 0.46, p = 0.056), while such correlation was not present for LMW adiponectin. Whole-body insulin sensitivity and intramyocellular triacylglycerol content were not affected by moderate alcohol consumption.
CONCLUSIONS/INTERPRETATION: Moderate alcohol consumption increases adiponectin concentrations, and in particular HMW adiponectin. Concentrations of HMW adiponectin in particular were positively associated with skeletal muscle oxidative capacity.
目的/假设：本研究旨在调查适度饮酒是否会增加血浆高分子量（HMW）脂联素和/或肌肉氧化能力。
在一项随机、对照、交叉试验中，11名瘦人（BMI 18 - 25 kg/m²）和8名超重者（BMI≥27 kg/m²）男性每天饮用100毫升威士忌（约32克酒精）或水，持续4周。在每个治疗期结束后，采集肌肉活检样本和空腹血样。
适度饮酒4周后，脂联素浓度升高（p < 0.001），升高了12.5%。适度饮酒倾向于使HMW脂联素升高57%（p = 0.07），中分子量脂联素升高12.5%（p = 0.07），但对低分子量（LMW）脂联素无影响。适度饮酒后，骨骼肌柠檬酸合酶、细胞色素c氧化酶和β - 3 - 羟酰基辅酶A脱氢酶（β - HAD）活性未发生变化，但在细胞色素c氧化酶（p = 0.072）和柠檬酸合酶（p = 0.102）活性方面观察到饮酒与BMI之间存在相互作用。在瘦男性中，适度饮酒倾向于使细胞色素c氧化酶（p = 0.08）和柠檬酸合酶活性（p = 0.12）分别升高23%和26%，但在超重男性中未出现这种情况。特别是，血浆HMW脂联素与骨骼肌柠檬酸合酶活性（r = 0.64，p = 0.009）、细胞色素c氧化酶（r = 0.59，p = 0.009）和β - HAD（r = 0.46，p = 0.056）呈正相关，而LMW脂联素不存在这种相关性。适度饮酒未影响全身胰岛素敏感性和肌细胞内三酰甘油含量。
结论/解读：适度饮酒会增加脂联素浓度，尤其是HMW脂联素。特别是HMW脂联素浓度与骨骼肌氧化能力呈正相关。
