利用全病毒微阵列诊断人偏肺病毒引起的重症呼吸系统疾病
Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray.
作者信息
Chiu Charles Y, Alizadeh Ash A, Rouskin Silvi, Merker Jason D, Yeh Elaine, Yagi Shigeo, Schnurr David, Patterson Bruce K, Ganem Don, DeRisi Joseph L
机构信息
Department of Biochemistry and Biophysics, University of California, San Francisco at Mission Bay, office BH403C, QB3 building, 1700 4th Street, San Francisco CA 94158, USA.
出版信息
J Clin Microbiol. 2007 Jul;45(7):2340-3. doi: 10.1128/JCM.00364-07. Epub 2007 May 9.
Abstract
A pan-virus DNA microarray (Virochip) was used to detect a human metapneumovirus (hMPV) strain associated with a critical respiratory tract infection in an elderly adult with chronic lymphocytic leukemia. This infection had previously eluded diagnosis despite extensive microbiological testing for possible etiologic agents. The patient's hMPV strain did not grow in viral culture, and only one of five specific reverse transcription-PCR assays for hMPV was positive.
摘要
使用全病毒DNA微阵列（病毒芯片）检测到一名患有慢性淋巴细胞白血病的老年成人中与严重呼吸道感染相关的人偏肺病毒（hMPV）毒株。尽管对可能的病原体进行了广泛的微生物检测，但此前该感染一直未能确诊。患者的hMPV毒株在病毒培养中未生长，并且针对hMPV的五种特异性逆转录 - 聚合酶链反应检测中只有一种呈阳性。
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