Russell Michael Bjørn
Head and Neck Research Group, Akershus University Hospital, Dr. Kobros vei 39, 1474, Nordbyhagen, Oslo, Norway.
J Headache Pain. 2007 Apr;8(2):71-6. doi: 10.1007/s10194-007-0366-y. Epub 2007 May 11.
The objective of this study was to investigate the importance of genetics in tension-type headache. A MEDLINE search from 1966 to December 2006 was performed for "tension-type headache and prevalence" and "tension-type headache and genetics". The prevalence of tension-type headache varies from 11 to 93%, with a slight female preponderance. Co-occurrence of migraine increases the frequency of tension-type headache. A family study of chronic tension-type headache suggests that genetic factors are important. A twin study analysing tension-type headache in migraineurs found that genetic factors play a minor role in episodic tension-type headache. Another twin study analysing twin pairs without co-occurrence of migraine showed a significantly higher concordance rate among monozygotic than same-gender dizygotic twin pairs with no or frequent episodic tension-type headache, while the difference was minor in twin pairs with infrequent episodic tension-type headache. Frequent episodic and chronic tension-type headache is caused by a combination of genetic and environmental factors, while infrequent episodic tension-type headache is caused primarily by environmental factors.
本研究的目的是调查遗传学在紧张型头痛中的重要性。对1966年至2006年12月期间的MEDLINE数据库进行检索，检索词为“紧张型头痛与患病率”以及“紧张型头痛与遗传学”。紧张型头痛的患病率在11%至93%之间，女性略占优势。偏头痛的并发会增加紧张型头痛的发作频率。一项关于慢性紧张型头痛的家族研究表明遗传因素很重要。一项对偏头痛患者紧张型头痛的双生子研究发现，遗传因素在发作性紧张型头痛中起次要作用。另一项对无偏头痛并发的双生子对进行分析的双生子研究显示，在无发作或频繁发作性紧张型头痛的同性别双卵双生子对中，单卵双生子对的一致性率显著高于双卵双生子对，而在发作不频繁的发作性紧张型头痛双生子对中，差异较小。频繁发作性和慢性紧张型头痛是由遗传和环境因素共同导致的，而发作不频繁的发作性紧张型头痛主要由环境因素引起。
