Vanholme Bartel, Grunewald Wim, Bateman Alex, Kohchi Takayuki, Gheysen Godelieve
Faculty of Bioscience Engineering, Department of Molecular Biotechnology, Ghent University, Coupure links 653, B-9000 Ghent, Belgium.
Trends Plant Sci. 2007 Jun;12(6):239-44. doi: 10.1016/j.tplants.2007.04.004. Epub 2007 May 10.
The ZIM domain was originally identified in the ZIM protein (BAA97679; Zinc-finger protein expressed in Inflorescence Meristem). Since then it has been found in other proteins and the corresponding genes have been grouped into a plant-specific family. However, the family lacks consistency in its classification among different databases. Here, we try to clarify this incongruity by presenting an overview of the Arabidopsis proteins having this domain. The presented genome-wide survey can be seen as a start point to reveal the unknown function of these proteins. Furthermore, because of the confusing ZIM nomenclature being used at present, we propose to rename the domain and family as tify, after the most conserved amino acid motif characterizing the members of this family.
ZIM结构域最初是在ZIM蛋白（BAA97679；在花序分生组织中表达的锌指蛋白）中鉴定出来的。从那时起，它在其他蛋白质中也被发现，相应的基因已被归为一个植物特有的家族。然而，该家族在不同数据库中的分类缺乏一致性。在这里，我们通过概述具有该结构域的拟南芥蛋白来试图澄清这种不一致。所呈现的全基因组调查可被视为揭示这些蛋白未知功能的起点。此外，由于目前使用的ZIM命名法令人困惑，我们建议根据该家族成员最保守的氨基酸基序，将该结构域和家族重新命名为tify。
