Busch Silke, Braus Gerhard H
Institut für Molekulare Mikrobiologie und Genetik, Georg-August - Universität Göttingen, D-37077 Göttingen, Germany.
Mol Microbiol. 2007 May;64(4):873-6. doi: 10.1111/j.1365-2958.2007.05711.x.
It is a challenge in biology to explore the molecular and cellular mechanisms necessary to form a complex three-dimensional structure composed of different cell types. Interesting models to study the underlying processes are fungi that can transform their wire-like hyphal filaments into complex and sometimes container-like fruit bodies. In the past, the role of developmental triggers and transcription factors was a major focus of research on fungal model organisms. In this issue of Molecular Microbiology, Nowrousian and collaborators report that fruit body development of the model organism Sordaria macrospora includes a novel player, a specific membrane protein of the endoplasmic reticulum that is not required for vegetative growth. This finding represents an important step towards connecting regulation of development with the co-ordinated changes in cellular compartments.
在生物学中，探索形成由不同细胞类型组成的复杂三维结构所需的分子和细胞机制是一项挑战。研究潜在过程的有趣模型是真菌，它们可以将丝状菌丝转化为复杂的、有时像容器一样的子实体。过去，发育触发因素和转录因子的作用是真菌模式生物研究的主要焦点。在本期《分子微生物学》中，诺鲁西安及其合作者报告称，模式生物大孢粪壳菌的子实体发育包括一个新成员，一种内质网的特定膜蛋白，营养生长不需要它。这一发现代表了朝着将发育调控与细胞区室的协调变化联系起来迈出的重要一步。
