Baliki Marwan N, Geha Paul Y, Apkarian A Vania
Northwestern University Feinberg School of Medicine, Department of Physiology, Chicago, IL 60611, USA.
Curr Pain Headache Rep. 2007 Jun;11(3):171-7. doi: 10.1007/s11916-007-0187-3.
Functional brain imaging studies in chronic neuropathic pain patients have lagged far behind equivalent studies in acute pain. In the past few years, this trend has begun to shift. This article discusses the novel approach of studying brain activity for spontaneous pain and its modulation by pharmacologic manipulation. We argue that the approach provides a solid methodology for studying clinical (especially neuropathic) pain and patient populations, and moreover, that the latest results using this approach imply that distinct clinical chronic pain conditions seem to involve specific brain circuitry, which is also distinct from the brain activity commonly observed in acute pain.
针对慢性神经性疼痛患者的功能性脑成像研究，远远落后于针对急性疼痛的同类研究。在过去几年中，这种趋势已开始转变。本文讨论了研究自发性疼痛的脑活动及其通过药物操作进行调节的新方法。我们认为，该方法为研究临床（尤其是神经性）疼痛及患者群体提供了坚实的方法，此外，使用该方法的最新结果表明，不同的临床慢性疼痛状况似乎涉及特定的脑回路，这也与急性疼痛中常见的脑活动不同。
