Patel Roshan, Mahobia Naveen, Upwar Nitin, Waseem Naheed, Talaviya Hetal, Patel Zalak
Shree Leuva Patel Trust Pharmacy Mahila College, Amreli, Gujarat, India.
J Adv Pharm Technol Res. 2010 Oct;1(4):415-8. doi: 10.4103/0110-5558.76441.
Plant Momordica charantia Linn. belongs to family Cucurbitaceae. It is known as bitter gourd in English and karela in Hindi. Earlier claims show that the plant is used in stomachic ailments as a carminative tonic; as an antipyretic and antidiabetic agent; and in rheumatoid arthritis and gout. The fruit has been claimed to contain charantin, steroidal saponin, momordium, carbohydrates, mineral matters, ascorbic acid, alkaloids, glucosides, etc. The ethanolic extract of the fruit showed the presence of alkaloids, tannins, glycosides, steroids, proteins, and carbohydrates. The present study was carried out using acetic acid-induced writhing and tail-immersion tests in mice, while yeast-induced pyrexia in rats. The ethanolic extracts (250 and 500 mg/kg, po.) showed an analgesic and antipyretic effect, which was significantly higher than that in the control rats. The observed pharmacological activities provide the scientific basis to support traditional claims as well as explore some new and promising leads.
植物苦瓜属于葫芦科。它在英语中被称为苦瓜，在印地语中被称为卡雷拉。早期的说法表明，该植物作为一种驱风滋补剂用于治疗胃部疾病；作为解热剂和抗糖尿病药物；以及用于治疗类风湿性关节炎和痛风。据称，该果实含有苦瓜素、甾体皂苷、苦瓜属、碳水化合物、矿物质、抗坏血酸、生物碱、糖苷等。该果实的乙醇提取物显示含有生物碱、单宁、糖苷、类固醇、蛋白质和碳水化合物。本研究使用乙酸诱导的小鼠扭体试验和尾部浸入试验，以及酵母诱导的大鼠发热试验进行。乙醇提取物（250和500毫克/千克，口服）显示出镇痛和解热作用，显著高于对照大鼠。观察到的药理活性为支持传统说法以及探索一些新的有前景的线索提供了科学依据。
