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负载德氏提取物的壳聚糖纳米颗粒：体内表征及抗原毒性研究

Chitosan Nanoparticles Loaded with Decne Extract: Insights into Characterization and Antigenotoxicity In Vivo.

作者信息

Salman Asmaa S, Alkhatib Shaza N, Ahmed Fatimah M, Hamouda Ragaa A

机构信息

Biology Department, College of Science and Arts at Khulis, University of Jeddah, Jeddah 21959, Saudi Arabia.

Genetic and Cytology Department, Biotechnology Research Institute, National Research Center, Cairo 12622, Egypt.

出版信息

Pharmaceutics. 2023 Oct 29;15(11):2551. doi: 10.3390/pharmaceutics15112551.

DOI:10.3390/pharmaceutics15112551
PMID:38004531
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10675202/
Abstract

Plant-based foods may enhance the prevention of cancer. The present investigation aimed to assess the antigenotoxic effects of chitosan nanoparticles (CNPs) when loaded with the ethanol extract of (CNPs/Cc). Synthesis of CNPs and CNPs/Cc and their characterization were carried out using TEM, EDS, DSC, and Zeta potential. For in vivo experiments, animal groups were treated in the following groups: negative control, ethyl methanesulfonate (EMS) (240 mg/kg), CNPs (350 mg/kg), high and low doses of CNPs/Cc, CNPs plus EMS, high dose of CNPs/Cc plus EMS, and low dose of CNPs/Cc plus EMS. Bone marrow chromosomal aberrations and sperm shape abnormalities were examined. TEM results showed that CNPs and CNPs/Cc are spherical particles. CNPs' physical stability was observed to be lower than that of CNPs/Cc due to the presence of more positive charges on CNPs/Cc. EMS significantly enhanced chromosomal abnormalities and sperm shape abnormalities. CNPs showed powerful antigenotoxic properties. For the first time, it could be concluded that loading chitosan nanoparticles with extract significantly promotes its protective properties.

摘要

植物性食物可能会增强癌症预防效果。本研究旨在评估负载有[具体植物名称]乙醇提取物的壳聚糖纳米颗粒（CNPs/Cc）的抗基因毒性作用。使用透射电子显微镜（TEM）、能谱仪（EDS）、差示扫描量热法（DSC）和zeta电位对CNPs和CNPs/Cc进行合成及表征。对于体内实验，动物分组如下：阴性对照组、甲磺酸乙酯（EMS）（240毫克/千克）、CNPs（350毫克/千克）、高剂量和低剂量的CNPs/Cc、CNPs加EMS、高剂量的CNPs/Cc加EMS以及低剂量的CNPs/Cc加EMS。检测骨髓染色体畸变和精子形态异常情况。TEM结果显示CNPs和CNPs/Cc为球形颗粒。由于CNPs/Cc上存在更多正电荷，观察到CNPs的物理稳定性低于CNPs/Cc。EMS显著增强了染色体异常和精子形态异常。CNPs表现出强大的抗基因毒性特性。首次可以得出结论，用[具体植物名称]提取物负载壳聚糖纳米颗粒可显著提升其保护特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/ad138825fa0b/pharmaceutics-15-02551-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/31ea9698faa0/pharmaceutics-15-02551-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/4d6a4d240bc8/pharmaceutics-15-02551-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/95b7549960db/pharmaceutics-15-02551-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/5761e3726d20/pharmaceutics-15-02551-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/006ea7e56750/pharmaceutics-15-02551-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/0b99585e5e6c/pharmaceutics-15-02551-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/b7b2ed3a66d9/pharmaceutics-15-02551-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/ad138825fa0b/pharmaceutics-15-02551-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/31ea9698faa0/pharmaceutics-15-02551-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/4d6a4d240bc8/pharmaceutics-15-02551-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/95b7549960db/pharmaceutics-15-02551-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/5761e3726d20/pharmaceutics-15-02551-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/006ea7e56750/pharmaceutics-15-02551-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/0b99585e5e6c/pharmaceutics-15-02551-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/b7b2ed3a66d9/pharmaceutics-15-02551-g007a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a41f/10675202/ad138825fa0b/pharmaceutics-15-02551-g008.jpg

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本文引用的文献

[1]
Salix subserrata Bark Extract-Loaded Chitosan Nanoparticles Attenuate Neurotoxicity Induced by Sodium Arsenate in Rats in Relation with HPLC-PDA-ESI-MS/MS Profile.

AAPS PharmSciTech. 2022-12-15

[2]
Chitin Nanocomposite Based on Plasticized Poly(lactic acid)/Poly(3-hydroxybutyrate) (PLA/PHB) Blends as Fully Biodegradable Packaging Materials.

Polymers (Basel). 2022-8-3

[3]
Determination of potential thresholds for N-ethyl-N-nitrosourea and ethyl methanesulfonate based on a multi-endpoint genotoxicity assessment platform in rats.

Environ Sci Pollut Res Int. 2022-12

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Anticancer, antioxidant, antiviral and antimicrobial activities of Kei Apple (Dovyalis caffra) fruit.

Sci Rep. 2022-4-8

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Plant-Based Diets and Cancer Risk: What is the Evidence?

Curr Nutr Rep. 2022-6

[6]
Assessment of the Antigenotoxic Effects of Alginate and ZnO/Alginate-Nanocomposites Extracted from Brown Alga in Mice.

Polymers (Basel). 2021-11-6

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Cancer Cell Int. 2021-6-24

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The ever-increasing importance of cancer as a leading cause of premature death worldwide.

Cancer. 2021-8-15

[9]
The Genome-Wide EMS Mutagenesis Bias Correlates With Sequence Context and Chromatin Structure in Rice.

Front Plant Sci. 2021-3-24

[10]
Mitomycin C induced genotoxic stress in endothelial cells is associated with differential expression of proinflammatory cytokines.

Mutat Res Genet Toxicol Environ Mutagen. 2020

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