Birch Eileen E, Cheng Christina S, Felius Joost
Retina Foundation of the Southwest, Dallas, TX 75231, USA.
J AAPOS. 2007 Oct;11(5):473-9. doi: 10.1016/j.jaapos.2007.02.011. Epub 2007 May 23.
The Children's Visual Function Questionnaire (CVFQ) is a vision-specific quality-of-life instrument designed for use with children up to 7 years of age. The goal of this study was to assess the construct validity of CVFQ subscales by examining their sensitivity to four research questions commonly posed in ophthalmic clinical trials.
CVFQ Competence, Personality, Family Impact, and Treatment Difficulty subscale scores were compared for groups of pediatric patients with unilateral versus bilateral disease (35 bilateral and 38 unilateral cataract), different severity of visual impairment (61 retinopathy of prematurity [ROP] grouped by acuity), difficulty of treatment regimen (22 optical, 44 surgery, 38 surgery with optical, and 35 surgery with optical and occlusion), and alternative treatments for the same condition (24 intraocular lenses, 37 aphakic contact lenses).
Patients treated for bilateral cataracts had significantly worse Competence subscale scores than patients treated for unilateral cataract, and patients with bilateral severe ROP (visual acuity 20/200 or poorer in both eyes) had significantly worse Competence subscale scores than other patients with ROP. Treatment Difficulty subscale scores were worse for patients with unilateral cataracts than for those with bilateral cataracts, worse for patients treated with occlusion therapy than for those treated with surgery or optical correction, and worse for those treated with an aphakic contact lens than for those treated with an intraocular lens. Family Impact subscale scores were worse for patients with unilateral cataracts than for those with bilateral cataracts, worse for patients treated with surgery than for those treated with optical correction, and worse for those with severe bilateral ROP than for any other patients with ROP.
The CVFQ subscales quantified meaningful differences among pediatric patient groups who were chosen to address key research questions commonly posed in ophthalmic clinical trials.
儿童视觉功能问卷（CVFQ）是一种专门针对视力的生活质量评估工具，适用于7岁及以下儿童。本研究的目的是通过检验儿童视觉功能问卷各分量表对眼科临床试验中常见的四个研究问题的敏感性，来评估其结构效度。
比较了患有单侧与双侧疾病的儿科患者组（35例双侧白内障和38例单侧白内障）、不同视力损害严重程度的患者组（61例按视力分组的早产儿视网膜病变[ROP]）、治疗方案难度不同的患者组（22例光学治疗、44例手术治疗、38例手术联合光学治疗以及35例手术联合光学治疗和遮盖治疗）以及针对相同病情的不同治疗方法的患者组（24例人工晶状体、37例无晶状体隐形眼镜）的儿童视觉功能问卷能力、个性、家庭影响和治疗难度分量表得分。
接受双侧白内障治疗的患者的能力分量表得分显著低于接受单侧白内障治疗的患者，双侧严重ROP患者（双眼视力均为20/200或更差）的能力分量表得分显著低于其他ROP患者。单侧白内障患者的治疗难度分量表得分高于双侧白内障患者，接受遮盖治疗的患者得分高于接受手术或光学矫正治疗的患者，接受无晶状体隐形眼镜治疗的患者得分高于接受人工晶状体治疗的患者。单侧白内障患者的家庭影响分量表得分高于双侧白内障患者，接受手术治疗的患者得分高于接受光学矫正治疗的患者，双侧严重ROP患者的得分高于其他任何ROP患者。
儿童视觉功能问卷各分量表量化了为解决眼科临床试验中常见关键研究问题而选取的儿科患者组之间的有意义差异。
