Longo Vincenzo, Chirulli Vera, Gervasi Pier Giovanni, Nencioni Simona, Pellegrini Michela
Laboratory of Pharmacogenetics and Drug Metabolism, Istituto di Fisiologia Clinica, CNR, via Moruzzi, 1, Pisa, 56100, Italy.
Biotechnol Lett. 2007 Aug;29(8):1155-9. doi: 10.1007/s10529-007-9378-6. Epub 2007 May 22.
Lisosan G is a powder of grain registered as an alimentary integrator. The treatment of rats for 4 days with 0.5 g Lisosan G/kg had no effect on various drug metabolizing enzymes. Experiments in vitro showed that Lisosan G had radical scavenger activity. A confirmation of the antioxidative property of Lisosan G was also confirmed when it was administered in vivo to carbon tetrachloride (CCl(4))-intoxicated rats. The toxicity caused by CCl(4)-treatment of rats was restored to the control levels when the rats were given Lisosan G for 4 days before CCl(4). Lisosan G thus does not interfere with drug metabolizing system but has antioxidant properties and protects against CCl(4)-induced hepatotoxicity.
Lisosan G是一种注册为营养强化剂的谷物粉末。用0.5克Lisosan G/千克对大鼠进行4天治疗，对各种药物代谢酶没有影响。体外实验表明，Lisosan G具有自由基清除活性。当在体内给四氯化碳（CCl₄）中毒的大鼠施用Lisosan G时，也证实了其抗氧化特性。在给予CCl₄之前，先给大鼠服用Lisosan G 4天，CCl₄处理大鼠所引起的毒性恢复到了对照水平。因此，Lisosan G不会干扰药物代谢系统，但具有抗氧化特性，并能预防CCl₄诱导的肝毒性。
