一种作为生物/微纳界面的超薄聚二甲基硅氧烷（PDMS）膜：制备与表征

An ultra-thin PDMS membrane as a bio/micro-nano interface: fabrication and characterization.

作者信息

Thangawng Abel L, Ruoff Rodney S, Swartz Melody A, Glucksberg Matthew R

机构信息

Mechanical Engineering Department, Northwestern University, Evanston, IL, USA.

出版信息

Biomed Microdevices. 2007 Aug;9(4):587-95. doi: 10.1007/s10544-007-9070-6.

DOI:10.1007/s10544-007-9070-6

PMID:17516172

Abstract

We report a method for making ultra-thin PDMS membrane devices. Freely suspended membranes as thin as 70 nm have been fabricated. Bulging tests were performed with a custom built fluidic cell to characterize large circular membranes. The fluidic cell allows the media (such as air or water) to wet one side of the membrane while maintaining the other side dry. Pressure was applied to the membrane via a liquid manometer through the fluidic cell. The resulting load-deflection curves show membranes that are extremely flexible, and they can be reproducibly loaded and unloaded. Such devices may potentially be used as mechanical and chemical sensors, and as a bio-nano/micro interface to study cellular mechanics in both static and dynamic environments.

摘要

我们报道了一种制造超薄聚二甲基硅氧烷（PDMS）膜器件的方法。已制造出厚度仅为70纳米的自由悬浮膜。使用定制的流体池进行鼓胀测试，以表征大型圆形膜。该流体池能使介质（如空气或水）浸湿膜的一侧，同时保持另一侧干燥。通过流体池，利用液体压力计向膜施加压力。所得的载荷-挠度曲线表明膜具有极高的柔韧性，并且可以反复加载和卸载。此类器件有可能用作机械和化学传感器，以及作为生物纳米/微界面，用于在静态和动态环境中研究细胞力学。