集成聚二甲基硅氧烷微流控系统的组件

Components for integrated poly(dimethylsiloxane) microfluidic systems.

作者信息

Ng Jessamine M K, Gitlin Irina, Stroock Abraham D, Whitesides George M

机构信息

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA.

出版信息

Electrophoresis. 2002 Oct;23(20):3461-73. doi: 10.1002/1522-2683(200210)23:20<3461::AID-ELPS3461>3.0.CO;2-8.

DOI:10.1002/1522-2683(200210)23:20<3461::AID-ELPS3461>3.0.CO;2-8

PMID:12412113

Abstract

This review describes the design and fabrication of microfluidic systems in poly(dimethylsiloxane) (PDMS). PDMS is a soft polymer with attractive physical and chemical properties: elasticity, optical transparency, flexible surface chemistry, low permeability to water, and low electrical conductivity. Soft lithography makes fabrication of microfluidic systems in PDMS particularly easy. Integration of components, and interfacing of devices with the user, is also convenient and simpler in PDMS than in systems made in hard materials. Fabrication of both single and multilayer microfluidic systems is straightforward in PDMS. Several components are described in detail: a passive chaotic mixer, pneumatically actuated switches and valves, a magnetic filter, functional membranes, and optical components.

摘要

本综述描述了聚二甲基硅氧烷（PDMS）中微流体系统的设计与制造。PDMS是一种具有吸引人的物理和化学性质的软聚合物：弹性、光学透明性、灵活的表面化学性质、低水渗透性和低电导率。软光刻技术使得在PDMS中制造微流体系统特别容易。与由硬质材料制成的系统相比，在PDMS中组件的集成以及设备与用户的接口也更方便和简单。在PDMS中制造单层和多层微流体系统都很直接。详细描述了几个组件：无源混沌混合器、气动开关和阀门、磁过滤器、功能膜和光学组件。