Hutchings H A, Upton P, Cheung W-Y, Maddocks A, Eiser C, Williams J G, Russell I T, Jackson S, Jenney M E M
School of Medicine, University of Wales, Swansea, UK.
Arch Dis Child. 2007 Oct;92(10):855-60. doi: 10.1136/adc.2006.098947. Epub 2007 May 23.
The availability of health-related quality of life (HRQL) measures that are reliable, valid, brief and comprehensible and appropriate for use with UK children is limited. We report the validation of a HRQL measure suitable for UK use in healthy children, children with chronic disease conditions and socially disadvantaged children.
A total of 1238 children took part in the study, including healthy children as controls (n = 824) and five exemplar groups: children diagnosed with asthma (n = 87), diabetes (n = 103) or inflammatory bowel disease (IBD; n = 69), children in remission from cancer (n = 68) and children in public care (n = 87).
In phase I, the Manchester-Minneapolis Quality of Life instrument (MMQL) Child Form was translated into UK English. In phases II and III, the questionnaire was shortened and validated.
MMQL was anglicised and shortened to five components comprising 29 items. Good internal reliability was found with alpha reaching at least 0.69 for all subscales. Construct validity was established through moderate correlations with comparable PedsQL subscales (Pearson's r ranged from 0.38 to 0.58, p<0.01). Discriminant validity was also demonstrated in children with asthma and IBD, children in remission from cancer and children in public care, all of whom reported significantly lower HRQL than healthy children. Children with diabetes showed similar HRQL to their healthy peers. Good reproducibility and moderate responsiveness were demonstrated for the new measure.
The anglicised and shortened MMQL was shown to be valid and reliable and could be a valuable new tool for the assessment of HRQL in children.
适用于英国儿童的、可靠、有效、简短、易懂且合适的健康相关生活质量（HRQL）测量工具有限。我们报告了一种适用于英国健康儿童、患有慢性疾病的儿童以及社会弱势儿童的HRQL测量工具的验证情况。
共有1238名儿童参与了该研究，包括作为对照组的健康儿童（n = 824）以及五个示例组：被诊断为哮喘的儿童（n = 87）、糖尿病患儿（n = 103）或炎症性肠病（IBD；n = 69）、癌症缓解期儿童（n = 68）以及公共护理机构中的儿童（n = 87）。
在第一阶段，将曼彻斯特 - 明尼阿波利斯生活质量量表（MMQL）儿童版翻译成英式英语。在第二和第三阶段，对问卷进行了缩短和验证。
MMQL被英语化并缩短为包含29个条目的五个分量表。所有子量表的内部信度良好，α系数至少达到0.69。通过与可比的儿童生活质量量表（PedsQL）子量表的中度相关性建立了结构效度（Pearson相关系数r范围为0.38至0.58，p<0.01）。哮喘和IBD患儿、癌症缓解期儿童以及公共护理机构中的儿童也显示出判别效度，他们报告的HRQL均显著低于健康儿童。糖尿病患儿的HRQL与健康同龄人相似。新测量工具显示出良好的可重复性和中度反应性。
英语化且缩短后的MMQL被证明是有效且可靠的，可能成为评估儿童HRQL的有价值的新工具。
