1例乙肝表面抗原阴性的暴发性肝炎患者，其乙肝核心抗原IgM抗体持续存在超过7年。
A case of HBs antigen negative fulminant hepatitis with IgM antibody to hepatitis B core antigen persisting more than seven years.
作者信息
Suga M, Shibata K, Kodama T, Arima K, Yamada S, Yachi A
机构信息
Department of Internal Medicine (Section 1), Sapporo Medical College, Japan.
出版信息
Gastroenterol Jpn. 1991 Oct;26(5):661-5. doi: 10.1007/BF02781685.
A 33-year old dentist developed fulminant hepatitis. At admission, a test for IgM antibody to hepatitis B core antigen (IgM anti-HBc) was positive, while tests for HBsAg and HBeAg were negative. He was cured of the disease, but in follow-up examinations from 1983 to 1990 IgM anti-HBc was continuously detected with radioimmunoassay while HBsAg and HBV-DNA were absent in the serum. However, HBcAg was found in a biopsied liver specimen and a small quantity of HBV-DNA was detectable by polymerase chain reaction assay. These observation suggest that the continuous detection of IgM anti-HBc without HBsAg in serum is due to persistent HBV infection and HBV replication in the liver.
一名33岁的牙医患上了暴发性肝炎。入院时，乙肝核心抗原IgM抗体（IgM抗-HBc）检测呈阳性，而乙肝表面抗原（HBsAg）和乙肝e抗原（HBeAg）检测呈阴性。他的疾病得以治愈，但在1983年至1990年的随访检查中，通过放射免疫测定法持续检测到IgM抗-HBc，而血清中未检测到HBsAg和乙肝病毒DNA（HBV-DNA）。然而，在肝脏活检标本中发现了乙肝核心抗原（HBcAg），并且通过聚合酶链反应测定法可检测到少量HBV-DNA。这些观察结果表明，血清中持续检测到无HBsAg的IgM抗-HBc是由于肝脏中持续存在乙肝病毒感染和乙肝病毒复制。
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