Benedict Christian, Dimitrov Stoyan, Marshall Lisa, Born Jan
Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, Hs 23a, 23538 Lübeck, Germany.
Brain Behav Immun. 2007 Nov;21(8):1058-62. doi: 10.1016/j.bbi.2007.04.004. Epub 2007 May 23.
Growing evidence points towards a beneficial effect of sleep on immune function. Human studies indicate that the T cell mediated adaptive immune function including formation of antigen specific antibodies is facilitated by sleep. Along this line, here we aimed to dissociate the effect of sleep and circadian rhythm on circulating interleukin-7 (IL-7) and interleukin-15 (IL-15). These cytokines play a key role in the homeostatic regulation of naïve and memory T cell numbers and are critical for the differentiation of memory T cells. Serum IL-7 concentration and expression of membrane-bound IL-15 (mIL-15) on CD14(+) monocytes were measured in 18 men on two occasions: once during a regular 24-h sleep-wake cycle and another time during a 24-h period of continuous wakefulness. During sleep and especially during late sleep serum IL-7 concentrations were distinctly increased as compared to wakefulness (p<0.05). mIL-15 density on monocytes remained unchanged by sleep. The sleep-dependent increase in IL-7 concentration was associated with increased REM sleep, but did not correlate with concentrations of GH, cortisol or norepinephrine during sleep. The findings concur with the notion of a supportive influence of sleep on T cell function related to formation of T cell memory.
越来越多的证据表明睡眠对免疫功能具有有益影响。人体研究表明，睡眠有助于T细胞介导的适应性免疫功能，包括抗原特异性抗体的形成。据此，我们旨在区分睡眠和昼夜节律对循环白细胞介素-7（IL-7）和白细胞介素-15（IL-15）的影响。这些细胞因子在初始和记忆T细胞数量的稳态调节中起关键作用，对记忆T细胞的分化至关重要。在18名男性中进行了两次测量：一次在正常的24小时睡眠-觉醒周期中，另一次在24小时持续清醒期间。与清醒相比，睡眠期间尤其是睡眠后期血清IL-7浓度明显升高（p<0.05）。睡眠对单核细胞上的mIL-15密度没有影响。IL-7浓度的睡眠依赖性增加与快速眼动睡眠增加有关，但与睡眠期间生长激素、皮质醇或去甲肾上腺素的浓度无关。这些发现与睡眠对与T细胞记忆形成相关的T细胞功能具有支持性影响的观点一致。
