肺炎克雷伯菌中编码CMY-8和CTX-M-3β-内酰胺酶的269千碱基接合质粒pK29的测序及比较基因组分析
Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.
作者信息
Chen Ying-Tsong, Lauderdale Tsai-Ling, Liao Tsai-Lien, Shiau Yih-Ru, Shu Hung-Yu, Wu Keh-Ming, Yan Jing-Jou, Su Ih-Jen, Tsai Shih-Feng
机构信息
Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan.
出版信息
Antimicrob Agents Chemother. 2007 Aug;51(8):3004-7. doi: 10.1128/AAC.00167-07. Epub 2007 May 25.
Abstract
A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.
摘要
对一株肺炎克雷伯菌的一个269千碱基的接合质粒pK29进行了测序。该质粒含有多个抗微生物耐药基因，包括那些在IncHI2质粒的常见主干中编码CMY-8 AmpC型和CTX-M-3超广谱β-内酰胺酶的基因。比较基因组分析突出了耐药基因的传播机制。
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