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本文引用的文献

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Klebsiella pneumoniae isolate producing at least eight different beta-lactamases, including AmpC and KPC beta-lactamases.肺炎克雷伯菌分离株产生至少八种不同的β-内酰胺酶，包括AmpC和KPCβ-内酰胺酶。
Antimicrob Agents Chemother. 2007 Feb;51(2):800-1. doi: 10.1128/AAC.01143-06. Epub 2006 Dec 4.
2
Clonal spread of both oxyimino-cephalosporin- and cefoxitin-resistant Klebsiella pneumoniae isolates co-producing SHV-2a and DHA-1 beta-lactamase at a burns intensive care unit.在一家烧伤重症监护病房，同时产SHV-2a和DHA-1β-内酰胺酶的对氧亚氨基头孢菌素和头孢西丁耐药的肺炎克雷伯菌分离株的克隆传播。
Int J Antimicrob Agents. 2006 Dec;28(6):520-4. doi: 10.1016/j.ijantimicag.2006.07.019. Epub 2006 Nov 13.
3
Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate.pK245的完整核苷酸序列，这是一种98千碱基的质粒，赋予临床分离的肺炎克雷伯菌喹诺酮耐药性和超广谱β-内酰胺酶活性。
Antimicrob Agents Chemother. 2006 Nov;50(11):3861-6. doi: 10.1128/AAC.00456-06. Epub 2006 Aug 28.
4
Complete DNA sequence, comparative genomics, and prevalence of an IncHI2 plasmid occurring among extraintestinal pathogenic Escherichia coli isolates.肠外致病性大肠杆菌分离株中一种IncHI2质粒的完整DNA序列、比较基因组学及流行情况
Antimicrob Agents Chemother. 2006 Nov;50(11):3929-33. doi: 10.1128/AAC.00569-06. Epub 2006 Aug 28.
5
The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter.肠杆菌科、假单胞菌属和不动杆菌属中的β-内酰胺酶威胁
Trends Microbiol. 2006 Sep;14(9):413-20. doi: 10.1016/j.tim.2006.07.008. Epub 2006 Jul 31.
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ISCR elements: novel gene-capturing systems of the 21st century?插入序列共同重复元件：21世纪新型基因捕获系统？
Microbiol Mol Biol Rev. 2006 Jun;70(2):296-316. doi: 10.1128/MMBR.00048-05.
7
Isolation of plasmid pKM101 in the Stocker laboratory.
Mutat Res. 2006 Jun;612(3):151-164. doi: 10.1016/j.mrrev.2006.03.002. Epub 2006 May 23.
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Extended-spectrum beta-lactamases and plasmid-mediated AmpC enzymes among clinical isolates of Escherichia coli and Klebsiella pneumoniae from seven medical centers in Taiwan.台湾七个医学中心临床分离的大肠埃希菌和肺炎克雷伯菌中的超广谱β-内酰胺酶和质粒介导的AmpC酶
Antimicrob Agents Chemother. 2006 May;50(5):1861-4. doi: 10.1128/AAC.50.5.1861-1864.2006.
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Overview of the epidemiological profile and laboratory detection of extended-spectrum beta-lactamases.超广谱β-内酰胺酶的流行病学概况及实验室检测概述
Clin Infect Dis. 2006 Apr 15;42 Suppl 4:S153-63. doi: 10.1086/500662.
10
Extended-spectrum beta-lactamases: a clinical update.超广谱β-内酰胺酶：临床最新进展
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肺炎克雷伯菌中编码CMY-8和CTX-M-3β-内酰胺酶的269千碱基接合质粒pK29的测序及比较基因组分析

Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae.

作者信息

Chen Ying-Tsong, Lauderdale Tsai-Ling, Liao Tsai-Lien, Shiau Yih-Ru, Shu Hung-Yu, Wu Keh-Ming, Yan Jing-Jou, Su Ih-Jen, Tsai Shih-Feng

机构信息

Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan Town, Miaoli County 350, Taiwan.

出版信息

Antimicrob Agents Chemother. 2007 Aug;51(8):3004-7. doi: 10.1128/AAC.00167-07. Epub 2007 May 25.

DOI:10.1128/AAC.00167-07
PMID:17526756
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1932545/
Abstract

A 269-kilobase conjugative plasmid, pK29, from a Klebsiella pneumoniae strain was sequenced. The plasmid harbors multiple antimicrobial resistance genes, including those encoding CMY-8 AmpC-type and CTX-M-3 extended-spectrum beta-lactamases in the common backbone of IncHI2 plasmids. Mechanisms for dissemination of the resistance genes are highlighted in comparative genomic analyses.

摘要

对一株肺炎克雷伯菌的一个269千碱基的接合质粒pK29进行了测序。该质粒含有多个抗微生物耐药基因，包括那些在IncHI2质粒的常见主干中编码CMY-8 AmpC型和CTX-M-3超广谱β-内酰胺酶的基因。比较基因组分析突出了耐药基因的传播机制。