Tieken S M, Leidy H J, Stull A J, Mattes R D, Schuster R A, Campbell W W
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
Horm Metab Res. 2007 May;39(5):389-94. doi: 10.1055/s-2007-976545.
To examine whether solid versus liquid meal-replacement products differentially affect appetite and appetite-regulating hormones in older adults.
On two occasions, 9 subjects (age: 61+/-3 years; BMI: 25.6+/-1.3 kg/m (2)) consumed 25% of daily energy needs as solid or liquid meal-replacements of similar energy contents. Blood and appetite ratings were collected over 4 hours.
The post-prandial hunger composite (area under the curve) was lower following the solid versus liquid meal-replacement (p<0.005) and remained below baseline over 4 hours (p<0.05). Similar responses were observed with the desire to eat. The insulin and ghrelin composites were lower following the solid trial compared to the liquid [insulin: 5825 (range: 4676-11639) VS. 7170 (4472-14169) uIU/l x 240 min, p<0.01; ghrelin: -92798 (range: -269130-47528) VS. -56152 (range: -390855-30840) pg/ml x 240 min, p<0.05]. Ghrelin also remained below baseline over 4 hours (p<0.05). No differences in cholecystokinin and leptin were observed between products.
The consumption of comparable meal-replacement products in solid versus liquid versions with similar energy contents led to differential appetitive responses and should not be viewed as dietary equivalents in older adults.
研究固体与液体代餐产品对老年人食欲及食欲调节激素的影响是否存在差异。
9名受试者（年龄：61±3岁；体重指数：25.6±1.3kg/m²）分两次食用能量含量相似的固体或液体代餐，摄入量为每日能量需求的25%。在4小时内收集血液样本和食欲评分。
与液体代餐相比，固体代餐后的餐后饥饿综合评分（曲线下面积）更低（p<0.005），且在4小时内一直低于基线水平（p<0.05）。在进食欲望方面也观察到类似反应。与液体试验相比，固体试验后胰岛素和胃饥饿素综合评分更低[胰岛素：5825（范围：4676-11639）对7170（4472-14169）uIU/l×240分钟，p<0.01；胃饥饿素：-92798（范围：-269130-47528）对-56152（范围：-390855-30840）pg/ml×240分钟，p<0.05]。胃饥饿素在4小时内也一直低于基线水平（p<0.05）。两种产品在胆囊收缩素和瘦素方面未观察到差异。
食用能量含量相似的固体和液体代餐产品会导致不同的食欲反应，在老年人中不应将它们视为等同饮食。
