Yan Ying, Cook Julie, McQuillan Jay, Zhang Guifang, Hitzman Cory J, Wang Yian, Wiedmann Timothy S, You Ming
Department of Surgery, The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Neoplasia. 2007 May;9(5):401-5. doi: 10.1593/neo.07160.
Effective chemoprevention of lung cancer in high-risk patients through the administration of pharmacologic or nutritional agents is urgently needed. Aerosol inhalation can deliver chemopreventive agents directly to the respiratory tract to inhibit the tumorigenic process. In this study, polyphenon E (PolyE) and (-)-epigallocatechin-3-gallate (EGCG) were administered by aerosol delivery to A/J mice beginning 2 weeks after carcinogen treatment and continuing daily by inhalation throughout the remainder of the study (20 weeks). PolyE decreased tumor load by approximately 59%. However, EGCG, both at the same dose and at a higher dose, failed to inhibit lung carcinogenesis. These results indicate that aerosol delivery of PolyE, but not EGCG, may be a useful chemopreventive protocol in subjects at high risk for lung cancer.
迫切需要通过给予药理或营养制剂对高危患者进行有效的肺癌化学预防。气溶胶吸入可将化学预防剂直接递送至呼吸道以抑制致瘤过程。在本研究中，从致癌物处理后2周开始，通过气溶胶给药向A/J小鼠给予茶多酚E（PolyE）和（-）-表没食子儿茶素-3-没食子酸酯（EGCG），并在研究的剩余时间（20周）内每天通过吸入持续给药。PolyE使肿瘤负荷降低了约59%。然而，相同剂量和更高剂量的EGCG均未能抑制肺癌发生。这些结果表明，PolyE而非EGCG的气溶胶给药可能是肺癌高危受试者有用的化学预防方案。
