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构建血管——血管生物学中的干细胞模型。

Building blood vessels--stem cell models in vascular biology.

作者信息

Jakobsson Lars, Kreuger Johan, Claesson-Welsh Lena

机构信息

Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.

出版信息

J Cell Biol. 2007 Jun 4;177(5):751-5. doi: 10.1083/jcb.200701146. Epub 2007 May 29.

DOI:10.1083/jcb.200701146
PMID:17535968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2064276/
Abstract

Spheroids of differentiating embryonic stem cells, denoted embryoid bodies, constitute a high-quality model for vascular development, particularly well suited for loss-of-function analysis of genes required for early embryogenesis. This review examines vasculogenesis and angiogenesis in murine embryoid bodies and discusses the promise of stem cell-based models for the study of human vascular development.

摘要

正在分化的胚胎干细胞球体，即胚状体，构成了血管发育的优质模型，特别适合用于对早期胚胎发育所需基因进行功能丧失分析。本综述探讨了小鼠胚状体中的血管发生和血管生成，并讨论了基于干细胞的模型在研究人类血管发育方面的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2938/2064276/2200b6bb9491/jcb1770751f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2938/2064276/dca5018b5dd5/jcb1770751f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2938/2064276/2200b6bb9491/jcb1770751f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2938/2064276/dca5018b5dd5/jcb1770751f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2938/2064276/2200b6bb9491/jcb1770751f02.jpg

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1
Building blood vessels--stem cell models in vascular biology.构建血管——血管生物学中的干细胞模型。
J Cell Biol. 2007 Jun 4;177(5):751-5. doi: 10.1083/jcb.200701146. Epub 2007 May 29.
2
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Computational Model Exploring Characteristic Pattern Regulation in Periventricular Vessels.探索脑室周围血管特征模式调控的计算模型
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Current Progress in Vascular Engineering and Its Clinical Applications.血管工程学的当前进展及其临床应用。

本文引用的文献

1
Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo.源自人类胚胎干细胞的内皮细胞在体内形成持久的血管。
Nat Biotechnol. 2007 Mar;25(3):317-8. doi: 10.1038/nbt1287. Epub 2007 Feb 25.
2
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.成血管细胞的发育确定了人类胚胎干细胞分化培养中造血作用的起始。
Blood. 2007 Apr 1;109(7):2679-87. doi: 10.1182/blood-2006-09-047704.
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Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands.
Cells. 2022 Jan 31;11(3):493. doi: 10.3390/cells11030493.
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Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells.TGFβ1 和 WNT6 在 FGF2 和 BMP4 驱动的鼠胚胎干细胞内皮分化中的作用。
Angiogenesis. 2022 Feb;25(1):113-128. doi: 10.1007/s10456-021-09815-4. Epub 2021 Sep 3.
5
The pericyte microenvironment during vascular development.血管发育过程中的周细胞微环境。
Microcirculation. 2019 Nov;26(8):e12554. doi: 10.1111/micc.12554. Epub 2019 May 27.
6
Microvascular bioengineering: a focus on pericytes.微血管生物工程：聚焦于周细胞
J Biol Eng. 2019 Mar 29;13:26. doi: 10.1186/s13036-019-0158-3. eCollection 2019.
7
Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation.骨形态发生蛋白 9 调控小鼠胚胎干细胞分化过程中早期淋巴管内皮细胞的扩增。
Stem Cell Reports. 2019 Jan 8;12(1):98-111. doi: 10.1016/j.stemcr.2018.11.024. Epub 2018 Dec 27.
8
Characterization of tubular liquid crystal structure in embryonic stem cell derived embryoid bodies.胚胎干细胞来源的拟胚体中管状液晶结构的表征
Cell Biosci. 2017 Jan 3;7:3. doi: 10.1186/s13578-016-0130-6. eCollection 2017.
9
Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion.内皮细胞 Dll4-Notch 动力学的同步将血管从分支转变为扩张。
Elife. 2016 Apr 13;5:e12167. doi: 10.7554/eLife.12167.
10
Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis.靶向血管和白细胞通讯在血管生成、炎症和纤维化中的作用。
Nat Rev Drug Discov. 2016 Feb;15(2):125-42. doi: 10.1038/nrd.2015.2. Epub 2015 Nov 27.
小鼠发育的克隆分析揭示了卵黄囊血岛的多克隆起源。
Dev Cell. 2006 Oct;11(4):519-33. doi: 10.1016/j.devcel.2006.08.001.
4
Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow.血管分支形态发生的动力学：血液和组织流动的影响
Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jun;73(6 Pt 1):061907. doi: 10.1103/PhysRevE.73.061907. Epub 2006 Jun 14.
5
Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation.血小板衍生生长因子受体-β促进内皮细胞早期分化。
Blood. 2006 Sep 15;108(6):1877-86. doi: 10.1182/blood-2006-04-014894. Epub 2006 May 11.
6
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis.反式硫酸乙酰肝素增强VEGFR介导的血管生成。
Dev Cell. 2006 May;10(5):625-34. doi: 10.1016/j.devcel.2006.03.009.
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VEGF receptor signalling - in control of vascular function.血管内皮生长因子受体信号传导——调控血管功能
Nat Rev Mol Cell Biol. 2006 May;7(5):359-71. doi: 10.1038/nrm1911.
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Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue.内皮祖细胞和促血管生成造血细胞对肿瘤和缺血组织血管形成的作用。
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Early lymph vessel development from embryonic stem cells.胚胎干细胞早期淋巴管发育
Arterioscler Thromb Vasc Biol. 2006 May;26(5):1073-8. doi: 10.1161/01.ATV.0000217610.58032.b7. Epub 2006 Mar 16.
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Transplantation of umbilical cord blood-derived endothelial progenitor cells: a promising method of therapeutic revascularisation.脐带血来源的内皮祖细胞移植：一种有前景的治疗性血管再生方法。
Eur J Haematol. 2006 Jan;76(1):1-8. doi: 10.1111/j.1600-0609.2005.00579.x.