Ferrié Laurent, Reymond Sébastien, Capdevielle Patrice, Cossy Janine
Laboratoire de Chimie Organique, ESPCI, CNRS, 10 Rue Vauquelin, 75231 Paris Cedex 05, France.
Org Lett. 2007 Jun 21;9(13):2461-4. doi: 10.1021/ol070670a. Epub 2007 May 31.
A chemoselective synthesis of the macrocyclic core of leucascandrolide A has been achieved, utilizing highly enantioselective allylmetalations, an enantioselective Noyori reduction of a propargylic ketone and olefin metatheses as the key steps.
通过高度对映选择性烯丙基金属化反应、炔丙基酮的对映选择性诺伊里还原反应以及烯烃复分解反应作为关键步骤，实现了对白木香醇A大环核心的化学选择性合成。
