Bendeck Sandra E, Jacobe Heidi T
Department of Dermatology, University of Texas at Southwestern Medical Center, Dallas, Texas 75390-9069, USA.
Dermatol Ther. 2007 Mar-Apr;20(2):86-92. doi: 10.1111/j.1529-8019.2007.00116.x.
Good outcome measures are required to determine whether a therapy is effective, both in routine clinical practice and in experimental clinical trials. In disorders of skin thickening such as morphea and scleroderma, more commonly used outcome measures that use a subjective score based on palpated skin thickening are fraught with error. By contrast, measurements made by ultrasound have great promise as outcome measures that are quantitative, valid, reproducible, and responsive. Further studies should establish its role in the field. In this paper, the present authors used ultrasound to illustrate the criteria that are required to establish a technology-based outcome measure.
在常规临床实践和实验性临床试验中，都需要良好的疗效指标来确定一种治疗方法是否有效。在诸如硬斑病和硬皮病等皮肤增厚性疾病中，更常用的基于触诊皮肤增厚的主观评分疗效指标存在诸多误差。相比之下，超声测量作为一种定量、有效、可重复且有反应性的疗效指标，具有很大的前景。进一步的研究应确定其在该领域的作用。在本文中，作者使用超声来说明建立基于技术的疗效指标所需的标准。
